Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8825839 | 0.90 | EGFR (0.62) | EGFRKDM4EHTTLMNAHPGD | |
| SCHEMBL8825901 | 0.90 | MAPK1 (0.44) | EGFRPDE5AHTTLMNAPDGFRB | |
| SCHEMBL8825884 | 0.89 | ALDH1A1 (0.55) | EGFRERBB2KDM4EHTTLMNA | |
| SCHEMBL7524564 | 0.89 | EGFR (0.50) | EGFRERBB2KDM4EHTTPDGFRB | |
| SCHEMBL8795709 | 0.88 | EGFR (0.49) | EGFRERBB2PDE5AKDM4EHTT | |
| SCHEMBL8825554 | 0.88 | EGFR (0.57) | EGFRERBB2KDM4EHTTLMNA | |
| SCHEMBL8825977 | 0.88 | MAPK1 (0.55) | EGFRERBB2HTTLMNA | |
| SCHEMBL8825743 | 0.88 | HTT (0.55) | EGFRKDM4EHTTLMNAHPGD | |
| SCHEMBL7521999 | 0.88 | EGFR (0.50) | EGFRERBB2KDM4EHTTPDGFRB | |
| SCHEMBL8795238 | 0.87 | EGFR (0.47) | EGFRERBB2KDM4EHTTPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5661147-A | CYCLIC GUANOSINE MONOPHOSPHATE-SPECIFIC PHOSPHODIESTERASE INHIBITOR; TREATING CARDIOVASCULAR DISORDER | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-08-26 | — | — | US | disclosed |
| EP-0668280-A1 | IMIDAZOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-08-23 | — | — | EP | disclosed |