Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.40 |
| ▸ | IGFBP5 | P24593 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8825427 | 0.83 | HDAC6 (0.38) | P4HTMKDM4EALOX15HDAC6L3MBTL1 | |
| SCHEMBL8825609 | 0.76 | HDAC6 (0.38) | KDM4EHDAC6L3MBTL1KEAP1ALDH1A1 | |
| SCHEMBL19065185 | 0.70 | ALDH1A1 (0.46) | KDM4EHDAC6L3MBTL1KEAP1ALDH1A1 | |
| SCHEMBL27610096 | 0.70 | KDM4E (0.52) | P4HTMKDM4EKMT2AALOX15TSHR | |
| SCHEMBL14639439 | 0.69 | KDM4E (0.59) | KDM4EHDAC6L3MBTL1KEAP1ALDH1A1 | |
| SCHEMBL8834235 | 0.69 | KDM4E (0.50) | P4HTMKDM4EKMT2AALOX15TSHR | |
| SCHEMBL21873545 | 0.67 | KDM4E (0.48) | P4HTMKDM4EKMT2AALOX15TSHR | |
| SCHEMBL14919050 | 0.67 | KDM4E (0.58) | P4HTMKDM4EKMT2AALOX15TSHR | |
| SCHEMBL934791 | 0.67 | KDM4E (0.48) | P4HTMKDM4EKMT2AALOX15TSHR | |
| SCHEMBL7977800 | 0.67 | KDM4E (0.48) | P4HTMKDM4EKMT2AALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624943-A | Pyridine compounds which are useful as leukotriene-B4 -antagonists | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-04-29 | — | — | US | disclosed |
| EP-0651745-A1 | NEW PYRIDINE DERIVATIVES AS LEUKCOTRIENE B 4? ANTAGONISTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-05-10 | — | — | EP | disclosed |
| WO-1994002464-A1 | NEW PYRIDINE DERIVATIVES AS LEUKCOTRIENE B4 ANTAGONISTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-02-03 | — | — | WO | disclosed |