Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | PGK1 | P00558 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | STAT3 | P40763 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8825770 | 0.91 | MAPK1 (0.55) | MAPK1EGFRHTTNPC1MAPT | |
| SCHEMBL8825848 | 0.90 | EGFR (0.50) | PDE5AEGFRHTTPDGFRBLMNA | |
| SCHEMBL8825889 | 0.88 | MAPT (0.44) | MAPK1EGFRHTTNPC1MAPT | |
| SCHEMBL8825777 | 0.84 | EGFR (0.50) | EGFRPGK1PDGFRBLMNAFBP1 | |
| SCHEMBL7528662 | 0.84 | EGFR (0.52) | MAPK1PDE5AEGFRHTTNPC1 | |
| SCHEMBL8825813 | 0.84 | PKM (0.56) | MAPK1EGFRPGK1HTTNPC1 | |
| SCHEMBL8825716 | 0.80 | CCNC (0.51) | EGFRHTTNPC1MAPTRAB9A | |
| SCHEMBL8825839 | 0.80 | EGFR (0.62) | MAPK1EGFRHTTRAB9ASMN1; SMN2 | |
| SCHEMBL8825726 | 0.80 | EGFR (0.43) | PDE5AEGFRPGK1SMN1; SMN2PDGFRB | |
| SCHEMBL8825743 | 0.80 | HTT (0.55) | MAPK1EGFRHTTMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5661147-A | CYCLIC GUANOSINE MONOPHOSPHATE-SPECIFIC PHOSPHODIESTERASE INHIBITOR; TREATING CARDIOVASCULAR DISORDER | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-08-26 | — | — | US | disclosed |
| EP-0668280-A1 | IMIDAZOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-08-23 | — | — | EP | disclosed |