Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 5/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NAAA | Q02083 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8826104 | 0.94 | HRH3 (0.61) | LTA4HHRH4HRH3GRIN2BMEN1 | |
| SCHEMBL8826398 | 0.92 | HRH3 (0.64) | LTA4HHRH4HRH3GRIN2BNAAA | |
| SCHEMBL17285945 | 0.88 | LTA4H (0.56) | LTA4HHRH4HRH3GRIN2B | |
| SCHEMBL22878293 | 0.88 | LTA4H (0.56) | LTA4HHRH4HRH3GRIN2BNAAA | |
| SCHEMBL17284599 | 0.87 | LTA4H (0.55) | LTA4HHRH4HRH3GRIN2BNAAA | |
| SCHEMBL17282063 | 0.85 | LTA4H (0.53) | LTA4HHRH4HRH3GRIN2BMEN1 | |
| SCHEMBL3375289 | 0.84 | GRIN2B (0.61) | LTA4HHRH4HRH3GRIN2BNAAA | |
| SCHEMBL11251947 | 0.78 | HRH3 (0.67) | LTA4HHRH4HRH3GRIN2BNAAA | |
| SCHEMBL12797554 | 0.78 | TSHR (0.64) | LTA4HHRH3MEN1KMT2ASLC6A2 | |
| SCHEMBL3043427 | 0.78 | LTA4H (0.74) | LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5631401-A | Inhibitors of protein farnesyltransferase and squalene synthase | ABBOTT LABORATORIES (US) | 1997-05-20 | — | — | US | disclosed |
| WO-1995021815-A1 | CYCLOBUTANE DERIVATIVES AND THEIR USE AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE AND SQUALENE SYNTHASE | ABBOTT LABORATORIES (US) | 1995-08-17 | — | — | WO | disclosed |