Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 6/20 | 0.56 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NAAA | Q02083 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17285945 | 0.89 | LTA4H (0.56) | LTA4HPRMT5WDR77HRH3HRH4 | |
| SCHEMBL8825962 | 0.88 | LTA4H (0.54) | LTA4HHRH3HRH4NAAAGRIN2B | |
| SCHEMBL17284599 | 0.88 | LTA4H (0.55) | LTA4HPRMT5WDR77HRH3HRH4 | |
| SCHEMBL22878155 | 0.87 | GRIN2B (0.52) | LTA4HHRH3HRH4AGTR2KDM4E | |
| SCHEMBL8826104 | 0.85 | HRH3 (0.61) | LTA4HPRMT5WDR77HRH3HRH4 | |
| SCHEMBL17282063 | 0.85 | LTA4H (0.53) | LTA4HPRMT5WDR77HRH3HRH4 | |
| SCHEMBL8826398 | 0.84 | HRH3 (0.64) | LTA4HPRMT5WDR77HRH3HRH4 | |
| SCHEMBL22878382 | 0.81 | HTR2A (0.46) | PRMT5WDR77HRH3HRH4 | |
| SCHEMBL22878461 | 0.80 | HTR2A (0.48) | PRMT5WDR77HRH3HRH4ALDH1A1 | |
| SCHEMBL22878464 | 0.79 | SLC6A2 (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145929-B1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS WHICH ARE JAK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-01-13 | — | — | EP | disclosed |