Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | BCAT1 | P54687 | 6/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TTR | P02766 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1491962 | 0.87 | BCAT1 (0.53) | ALDH1A1MAPTBCAT1KDM4ELMNA | |
| SCHEMBL4226088 | 0.84 | NPC1 (0.60) | MAOBNPC1RAB9ATTRSMN1; SMN2 | |
| SCHEMBL26116873 | 0.83 | BCAT1 (0.57) | ALDH1A1MAPTBCAT1KDM4ELMNA | |
| SCHEMBL13044619 | 0.83 | MCHR1 (0.49) | ALDH1A1MAPTBCAT1LMNANPC1 | |
| SCHEMBL26570393 | 0.82 | BCAT1 (0.51) | ALDH1A1BCAT1KDM4ELMNANPC1 | |
| SCHEMBL6235025 | 0.82 | BCAT1 (0.59) | ALDH1A1MAPTBCAT1KDM4ELMNA | |
| SCHEMBL26575703 | 0.82 | BCAT1 (0.53) | ALDH1A1MAPTBCAT1KDM4ELMNA | |
| Trifluoroacetic Acid SCHEMBL29887191 | 0.80 | TP53 (0.50) | ALDH1A1BCAT1L3MBTL1KDM4ELMNA | |
| SCHEMBL11599094 | 0.78 | NPC1 (0.57) | ALDH1A1MAPTBCAT1KDM4ELMNA | |
| SCHEMBL11352725 | 0.77 | TTR (0.54) | ALDH1A1MAPTBCAT1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5631401-A | Inhibitors of protein farnesyltransferase and squalene synthase | ABBOTT LABORATORIES (US) | 1997-05-20 | — | — | US | disclosed |
| WO-1995021815-A1 | CYCLOBUTANE DERIVATIVES AND THEIR USE AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE AND SQUALENE SYNTHASE | ABBOTT LABORATORIES (US) | 1995-08-17 | — | — | WO | disclosed |