Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | MGLL | Q99685 | 9/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874883 | 0.91 | MGLL (0.50) | CYP1A2CYP3A4MGLLMEN1KMT2A | |
| SCHEMBL875939 | 0.83 | POLB (0.56) | MEN1KMT2A | |
| SCHEMBL875189 | 0.73 | POLB (0.58) | MEN1KMT2ACYP2C9SMN1; SMN2 | |
| SCHEMBL882700 | 0.72 | POLB (0.60) | MEN1KMT2A | |
| SCHEMBL3055869 | 0.68 | NAMPT (0.48) | CYP1A2CYP3A4MEN1KMT2ACYP2C9 | |
| SCHEMBL11389733 | 0.66 | CYP1A2 (1.00) | CYP1A2CYP3A4MEN1KMT2ACYP2D6 | |
| SCHEMBL3050177 | 0.66 | POLB (0.55) | MEN1KMT2AHTT | |
| SCHEMBL874893 | 0.66 | POLB (0.55) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17968065 | 0.65 | NOTUM (0.63) | RAB9AMAPK1SMN1; SMN2NOTUMNPC1 | |
| SCHEMBL8446322 | 0.64 | PTPN1 (0.52) | MGLLNOTUMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |