Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 12/20 | 1.00 |
| ▸ | KCNK3 | O14649 | 6/20 | 0.72 |
| ▸ | KCNK9 | Q9NPC2 | 6/20 | 0.72 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10069479 | 0.85 | KCNK3 (0.77) | F2RKCNK3KCNK9 | |
| SCHEMBL882775 | 0.82 | F2R (1.00) | F2RKCNK3KCNK9RXFP1 | |
| SCHEMBL882546 | 0.81 | KCNK3 (0.80) | F2RKCNK3KCNK9RXFP1 | |
| SCHEMBL9842887 | 0.81 | F2R (0.68) | F2R | |
| SCHEMBL882809 | 0.80 | F2R (1.00) | F2R | |
| SCHEMBL4753755 | 0.79 | KCNK3 (0.72) | F2RKCNK3KCNK9RXFP1 | |
| SCHEMBL30211340 | 0.79 | KCNK3 (0.72) | F2RKCNK3KCNK9RXFP1 | |
| SCHEMBL1197921 | 0.79 | KCNK3 (0.73) | F2RKCNK3KCNK9RXFP1 | |
| SCHEMBL882721 | 0.79 | F2R (1.00) | F2R | |
| SCHEMBL882806 | 0.79 | F2R (1.00) | F2RKCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9422262-B2 | Compounds and methods for treating diseases mediated by protease activated receptors | THE BROAD INSTITUTE, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| WO-2012040636-A2 | COMPOUNDS AND METHODS FOR TREATING DISEASES MEDIATED BY PROTEASE ACTIVATED RECEPTORS | THE BROAD INSTITUTE, INC. (US) | 2012-03-29 | — | — | WO | disclosed |