Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 8/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL882738 | 0.87 | F2R (0.70) | F2RLMNAMAPK10HSD17B10ALDH1A1 | |
| SCHEMBL18025116 | 0.84 | F2R (0.82) | F2RALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL29766853 | 0.83 | F2R (1.00) | F2RKMT2A | |
| SCHEMBL882467 | 0.83 | F2R (1.00) | F2RKMT2A | |
| SCHEMBL10069464 | 0.77 | F2R (0.70) | F2RLMNAALDH1A1MAPTHPGD | |
| SCHEMBL882468 | 0.76 | F2R (0.85) | F2RMAPK10ALDH1A1KMT2AMEN1 | |
| SCHEMBL13171396 | 0.76 | PNLIP (0.64) | F2RLMNAALDH1A1MAPTHPGD | |
| SCHEMBL882797 | 0.75 | F2R (1.00) | F2RLMNAALDH1A1 | |
| SCHEMBL882742 | 0.74 | F2R (1.00) | F2RALDH1A1 | |
| SCHEMBL10069483 | 0.74 | F2R (1.00) | F2RLMNAALDH1A1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9422262-B2 | Compounds and methods for treating diseases mediated by protease activated receptors | THE BROAD INSTITUTE, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| US-9422262-B2 | Compounds and methods for treating diseases mediated by protease activated receptors | THE BROAD INSTITUTE, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| WO-2012040636-A2 | COMPOUNDS AND METHODS FOR TREATING DISEASES MEDIATED BY PROTEASE ACTIVATED RECEPTORS | THE BROAD INSTITUTE, INC. (US) | 2012-03-29 | — | — | WO | disclosed |