Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 10/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874202 | 0.88 | F2R (0.70) | F2RKMT2AMEN1KCNK3SMN1; SMN2 | |
| SCHEMBL882798 | 0.87 | F2R (0.68) | F2RALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL10069466 | 0.87 | F2R (0.82) | F2RPOLBALDH1A1KMT2AMEN1 | |
| SCHEMBL882804 | 0.86 | KMT2A (0.72) | F2RALDH1A1KMT2AMEN1KCNK3 | |
| SCHEMBL10069967 | 0.86 | KMT2A (0.85) | F2RALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL882777 | 0.84 | F2R (0.66) | F2RALDH1A1KMT2AMEN1KCNK3 | |
| SCHEMBL882790 | 0.84 | KCNK9 (0.71) | F2RALDH1A1KMT2AMEN1KCNK3 | |
| SCHEMBL10975643 | 0.83 | F2R (0.73) | F2RPOLBALDH1A1TP53RAB9A | |
| SCHEMBL882805 | 0.83 | ADORA3 (0.64) | F2RALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL8278749 | 0.82 | F2R (0.65) | F2RALDH1A1KMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9422262-B2 | Compounds and methods for treating diseases mediated by protease activated receptors | THE BROAD INSTITUTE, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| US-9422262-B2 | Compounds and methods for treating diseases mediated by protease activated receptors | THE BROAD INSTITUTE, INC. (US) | 2016-08-23 | — | — | US | disclosed |
| WO-2012040636-A2 | COMPOUNDS AND METHODS FOR TREATING DISEASES MEDIATED BY PROTEASE ACTIVATED RECEPTORS | THE BROAD INSTITUTE, INC. (US) | 2012-03-29 | — | — | WO | disclosed |