Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 4/20 | 0.58 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8828191 | 1.00 | SPHK2 (0.58) | SPHK2SPHK1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8828205 | 0.96 | MAPK1 (0.60) | SPHK2SPHK1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9739796 | 0.85 | MAPK1 (0.57) | SPHK2SPHK1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL8828287 | 0.85 | MAPK1 (0.53) | MAPK1SMN1; SMN2ALDH1A1HRH3DRD2 | |
| SCHEMBL8828284 | 0.85 | MAPK1 (0.53) | MAPK1SMN1; SMN2ALDH1A1HRH3DRD2 | |
| SCHEMBL8828297 | 0.84 | MAPK1 (0.52) | MAPK1SMN1; SMN2ALDH1A1HRH3ABCB1 | |
| SCHEMBL8828289 | 0.84 | MAPK1 (0.52) | MAPK1SMN1; SMN2ALDH1A1HRH3ABCB1 | |
| SCHEMBL9372055 | 0.83 | HRH3 (0.68) | SPHK2SPHK1HRH3 | |
| SCHEMBL9374317 | 0.83 | HRH3 (0.68) | SPHK2SPHK1HRH3 | |
| SCHEMBL9372067 | 0.83 | HRH3 (0.68) | SPHK2SPHK1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607953-A | ANTIISCHEMIC AGENTS | EISAI CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| EP-0344577-B1 | Butenoic or propenoic acid derivatives | EISAI CO LTD (JP) | 1996-10-09 | — | — | EP | disclosed |
| US-5382595-A | Antiischemic agents | EISAI CO., LTD. (JP) | 1995-01-17 | — | — | US | disclosed |
| US-5177089-A | Antiischemic agent, vasodilator | EISAI CO., LTD. (JP) | 1993-01-05 | — | — | US | disclosed |
| US-5047417-A | Butenoic or propenoic acid derivatives | EISAI CO. LTD. (JP) | 1991-09-10 | — | — | US | disclosed |
| EP-0344577-A2 | Butenoic or propenoic acid derivatives | Eisai Co., Ltd. (JP) | 1989-12-06 | — | — | EP | disclosed |