Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.45 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8828205 | 0.89 | MAPK1 (0.60) | MAPK1ALDH1A1SMN1; SMN2KDM4ECRHBP | |
| SCHEMBL9740312 | 0.88 | MAPK1 (0.57) | MAPK1ALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL8828243 | 0.87 | MAPK1 (0.58) | MAPK1ALDH1A1SMN1; SMN2KDM4ECRHBP | |
| SCHEMBL8828191 | 0.85 | SPHK2 (0.58) | MAPK1ALDH1A1SMN1; SMN2LMNASPHK2 | |
| SCHEMBL8828199 | 0.85 | SPHK2 (0.58) | MAPK1ALDH1A1SMN1; SMN2LMNASPHK2 | |
| SCHEMBL26024359 | 0.84 | MAPK1 (0.55) | MAPK1ALDH1A1SMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL8828284 | 0.83 | MAPK1 (0.53) | MAPK1ALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL8828287 | 0.83 | MAPK1 (0.53) | MAPK1ALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL5191198 | 0.83 | MAPK1 (0.56) | MAPK1ALDH1A1SMN1; SMN2KDM4ECRHBP | |
| SCHEMBL8828312 | 0.81 | MAPK1 (0.57) | MAPK1ALDH1A1SMN1; SMN2KDM4ECRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| EP-0224794-B1 | CYCLIC AMINE DERIVATIVES, MEDICINES CONTAINING THESE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1990-09-12 | — | — | EP | disclosed |
| EP-0224794-A2 | Cyclic amine derivatives, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1987-06-10 | — | — | EP | disclosed |