Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.54 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8828199 | 0.96 | SPHK2 (0.58) | MAPK1SPHK2SPHK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8828191 | 0.96 | SPHK2 (0.58) | MAPK1SPHK2SPHK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9739796 | 0.89 | MAPK1 (0.57) | MAPK1SPHK2SPHK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL5191198 | 0.86 | MAPK1 (0.56) | MAPK1ALDH1A1SMN1; SMN2KDM4ECRHBP | |
| SCHEMBL8828243 | 0.85 | MAPK1 (0.58) | MAPK1ALDH1A1SMN1; SMN2KDM4ECRHBP | |
| SCHEMBL26024359 | 0.85 | MAPK1 (0.55) | MAPK1ALDH1A1SMN1; SMN2KDM4ESIGMAR1 | |
| SCHEMBL8828312 | 0.84 | MAPK1 (0.57) | MAPK1ALDH1A1SMN1; SMN2KDM4ECRHBP | |
| SCHEMBL9740312 | 0.84 | MAPK1 (0.57) | MAPK1ALDH1A1SMN1; SMN2KDM4ECRHBP | |
| SCHEMBL6807049 | 0.83 | HRH3 (0.63) | SPHK2SPHK1HRH3SIGMAR1 | |
| SCHEMBL9372352 | 0.83 | HRH3 (0.63) | SPHK2SPHK1HRH3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607953-A | ANTIISCHEMIC AGENTS | EISAI CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| EP-0344577-B1 | Butenoic or propenoic acid derivatives | EISAI CO LTD (JP) | 1996-10-09 | — | — | EP | disclosed |
| US-5382595-A | Antiischemic agents | EISAI CO., LTD. (JP) | 1995-01-17 | — | — | US | disclosed |
| US-5177089-A | Antiischemic agent, vasodilator | EISAI CO., LTD. (JP) | 1993-01-05 | — | — | US | disclosed |
| US-5047417-A | Butenoic or propenoic acid derivatives | EISAI CO. LTD. (JP) | 1991-09-10 | — | — | US | disclosed |
| EP-0344577-A2 | Butenoic or propenoic acid derivatives | Eisai Co., Ltd. (JP) | 1989-12-06 | — | — | EP | disclosed |