Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.61 |
| ▸ | IKBKB | O14920 | 1/20 | 0.58 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.51 |
| ▸ | METAP1 | P53582 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NAT1 | P18440 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5752284 | 1.00 | HSD11B1 (0.61) | HSD11B1IKBKBPIM1PIM2METAP1 | |
| SCHEMBL5752280 | 1.00 | HSD11B1 (0.61) | HSD11B1IKBKBPIM1PIM2METAP1 | |
| SCHEMBL5753273 | 0.89 | HSD11B1 (0.64) | HSD11B1IKBKBPIM1PIM2METAP1 | |
| SCHEMBL5753271 | 0.89 | HSD11B1 (0.64) | HSD11B1IKBKBPIM1PIM2METAP1 | |
| SCHEMBL5754714 | 0.88 | HSD11B1 (0.62) | HSD11B1IKBKBPIM1PIM2METAP1 | |
| SCHEMBL11325672 | 0.81 | AKR1C3 (0.56) | PIM1PIM2NPC1NAT1PARP1 | |
| SCHEMBL15828902 | 0.81 | KMT2A (0.58) | HSD11B1PIM1PIM2NPC1ALDH1A1 | |
| SCHEMBL11325775 | 0.81 | CYP1A2 (0.59) | PIM1PIM2NPC1ALDH1A1NAT1 | |
| SCHEMBL8883177 | 0.81 | CYP1A2 (0.59) | PIM1PIM2NPC1ALDH1A1NAT1 | |
| SCHEMBL9139338 | 0.79 | MIF (0.48) | HSD11B1PARP1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607953-A | ANTIISCHEMIC AGENTS | EISAI CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| EP-0344577-B1 | Butenoic or propenoic acid derivatives | EISAI CO LTD (JP) | 1996-10-09 | — | — | EP | disclosed |
| US-5382595-A | Antiischemic agents | EISAI CO., LTD. (JP) | 1995-01-17 | — | — | US | disclosed |
| US-5177089-A | Antiischemic agent, vasodilator | EISAI CO., LTD. (JP) | 1993-01-05 | — | — | US | disclosed |
| US-5047417-A | Butenoic or propenoic acid derivatives | EISAI CO. LTD. (JP) | 1991-09-10 | — | — | US | disclosed |
| EP-0344577-A2 | Butenoic or propenoic acid derivatives | Eisai Co., Ltd. (JP) | 1989-12-06 | — | — | EP | disclosed |