Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8183855 | 0.92 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNACYP2C19CASP3SENP8 | |
| SCHEMBL2541869 | 0.88 | CYP2C19 (0.52) | SMN1; SMN2LMNACYP2C19CASP3SENP8 | |
| SCHEMBL2541871 | 0.88 | CYP2C19 (0.52) | SMN1; SMN2LMNACYP2C19CASP3SENP8 | |
| SCHEMBL31187270 | 0.79 | LMNA (0.51) | SMN1; SMN2LMNAPOLBALDH1A1NPC1 | |
| SCHEMBL15204577 | 0.79 | SLC18A3 (0.60) | SMN1; SMN2LMNAALDH1A1L3MBTL1TDP1 | |
| SCHEMBL27089336 | 0.79 | GPR6 (0.43) | SMN1; SMN2LMNAALDH1A1L3MBTL1TDP1 | |
| SCHEMBL27089392 | 0.79 | NAPRT (0.59) | ALDH1A1L3MBTL1TDP1MAPT | |
| SCHEMBL950218 | 0.77 | LMNA (0.73) | SMN1; SMN2LMNACYP2C19CASP3SENP8 | |
| SCHEMBL105459 | 0.75 | SMN1; SMN2 (0.70) | SMN1; SMN2LMNACYP2C19CASP3SENP8 | |
| SCHEMBL17180592 | 0.75 | LMNA (0.70) | SMN1; SMN2LMNACYP2C19CASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688795-A | URINARY TRACTS OBSTRUCTION | SYNTEX (U.S.A.) INC. (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0711757-A1 | 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy -pyridine, pyrimidine and benzene derivatives as alpha1-adrenoceptor antagonists | F. Hoffmann-La Roche AG (CH) | 1996-05-15 | — | — | EP | disclosed |