Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | CASP3 | P42574 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8829283 | 0.90 | GRM5 (0.32) | L3MBTL1ALDH1A1HPGDKDM4E | |
| SCHEMBL8829204 | 0.82 | CYP1A2 (0.30) | HPGDCYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL5601168 | 0.77 | KCNH2 (0.34) | L3MBTL1ALDH1A1TDP1KDM4EHSD11B1 | |
| SCHEMBL8829207 | 0.73 | HRH3 (0.33) | L3MBTL1TDP1 | |
| SCHEMBL8829288 | 0.72 | NOS2 (0.37) | L3MBTL1ALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL8829116 | 0.72 | MEN1 (0.34) | MEN1KMT2A | |
| SCHEMBL5600229 | 0.72 | KCNH2 (0.41) | L3MBTL1TDP1CYP19A1HSD11B1 | |
| SCHEMBL8829270 | 0.71 | GAA (0.31) | ALDH1A1SMN1; SMN2MEN1KMT2ACYP1A2 | |
| SCHEMBL5602340 | 0.70 | KCNH2 (0.44) | L3MBTL1ALDH1A1TDP1KDM4ELMNA | |
| SCHEMBL5602394 | 0.70 | KCNH2 (0.44) | L3MBTL1ALDH1A1TDP1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5661158-A | HYPOTENSIVE AGENTS, ANTICHOLESTEROL AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-26 | — | — | US | disclosed |
| EP-0480204-B1 | Imidazole derivatives, potent and selective antagonists of angiotensin II receptor | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-03-20 | — | — | EP | disclosed |
| EP-0655915-A1 | USE OF ANGIOTENSIN II ANTAGONISTS FOR THE TREATMENT OF HYPERLIPIDAEME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-06-07 | — | — | EP | disclosed |
| US-5387592-A | Angiotensin converting enzyme inhibitors, calcium channel blockers, diuretics and adrenergic blocking agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-02-07 | — | — | US | disclosed |
| EP-0520723-B1 | Angiotensin II antagonists | ICI PLC (GB) | 1994-06-01 | — | — | EP | disclosed |
| WO-1994004153-A1 | USE OF ANGIOTENSIN II ANTAGONISTS FOR THE TREATMENT OF HYPERLIPIDAEME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-03-03 | — | — | WO | disclosed |
| US-5281613-A | Heterocyclic ring substituted benzofuran, benzothiofuran, or indole derivative | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-01-25 | — | — | US | disclosed |
| US-5215994-A | Treating or preventing hypertension or heart failure | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-06-01 | — | — | US | disclosed |
| US-5210092-A | Hypotensive agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-05-11 | — | — | US | disclosed |
| EP-0520723-A1 | Angiotensin II antagonists | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-12-30 | — | — | EP | disclosed |
| EP-0520724-A1 | Angiotensin II antagonists | ZENECA LIMITED (GB) | 1992-12-30 | — | — | EP | disclosed |
| EP-0480204-A1 | Imidazole derivatives, potent and selective antagonists of angiotensin II receptor | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-04-15 | — | — | EP | disclosed |