Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.59 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.59 |
| ▸ | LTB4R | Q15722 | 7/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8829411 | 1.00 | CYSLTR1 (0.59) | CYSLTR1CYSLTR2LTB4R | |
| SCHEMBL8829398 | 1.00 | CYSLTR1 (0.59) | CYSLTR1CYSLTR2LTB4R | |
| SCHEMBL8829425 | 0.90 | CYSLTR1 (0.59) | CYSLTR1CYSLTR2LTB4R | |
| SCHEMBL8829440 | 0.90 | CYSLTR1 (0.59) | CYSLTR1CYSLTR2LTB4R | |
| SCHEMBL8829428 | 0.90 | CYSLTR1 (0.59) | CYSLTR1CYSLTR2LTB4R | |
| SCHEMBL8829435 | 0.85 | LTB4R (0.56) | CYSLTR1CYSLTR2LTB4R | |
| SCHEMBL8829431 | 0.85 | LTB4R (0.56) | CYSLTR1CYSLTR2LTB4R | |
| SCHEMBL8829447 | 0.85 | LTB4R (0.56) | CYSLTR1CYSLTR2LTB4R | |
| SCHEMBL8829375 | 0.85 | CYSLTR1 (0.80) | CYSLTR1CYSLTR2LTB4R | |
| SCHEMBL8829374 | 0.85 | CYSLTR1 (0.80) | CYSLTR1CYSLTR2LTB4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0404440-B1 | Substituted sulfonamides and related compounds in the treatment of asthma, arthritis, and related diseases | PFIZER (US) | 1997-11-05 | — | — | EP | disclosed |
| US-5384318-A | Substituted sulfonamides and related compounds in the treatment of asthma, arthritis and related diseases | PFIZER INC. (US) | 1995-01-24 | — | — | US | disclosed |
| EP-0404440-A2 | Substituted sulfonamides and related compounds in the treatment of asthma, arthritis, and related diseases | PFIZER INC. (US) | 1990-12-27 | — | — | EP | disclosed |
| WO-1990015801-A1 | SUBSTITUTED SULFONAMIDES AND RELATED COMPOUNDS IN THE TREATMENT OF ASTHMA, ARTHRITIS AND RELATED DISEASES | PFIZER INC. (US) | 1990-12-27 | — | — | WO | disclosed |