Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 4/20 | 0.56 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.46 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.46 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8829435 | 1.00 | LTB4R (0.56) | LTB4RCYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL8829431 | 1.00 | LTB4R (0.56) | LTB4RCYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL8829411 | 0.85 | CYSLTR1 (0.59) | LTB4RCYSLTR1CYSLTR2 | |
| SCHEMBL8829402 | 0.85 | CYSLTR1 (0.59) | LTB4RCYSLTR1CYSLTR2 | |
| SCHEMBL8829398 | 0.85 | CYSLTR1 (0.59) | LTB4RCYSLTR1CYSLTR2 | |
| SCHEMBL8829427 | 0.85 | LTB4R (0.63) | LTB4RCYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL8829417 | 0.85 | LTB4R (0.63) | LTB4RCYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL8829415 | 0.85 | LTB4R (0.63) | LTB4RCYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL8524172 | 0.82 | LTB4R (0.69) | LTB4RCYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL8466039 | 0.82 | LTB4R (0.69) | LTB4RCYSLTR1CYSLTR2GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0404440-B1 | Substituted sulfonamides and related compounds in the treatment of asthma, arthritis, and related diseases | PFIZER (US) | 1997-11-05 | — | — | EP | disclosed |
| EP-0404440-A2 | Substituted sulfonamides and related compounds in the treatment of asthma, arthritis, and related diseases | PFIZER INC. (US) | 1990-12-27 | — | — | EP | disclosed |