Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.59 |
| ▸ | RAB9A | P51151 | 7/20 | 0.59 |
| ▸ | TP53 | P04637 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL417374 | 0.80 | NPC1 (0.61) | NPC1RAB9ATP53MAPTLMNA | |
| SCHEMBL28637876 | 0.76 | NPC1 (0.74) | NPC1RAB9ATP53MAPTLMNA | |
| SCHEMBL157198 | 0.76 | RAB9A (0.62) | NPC1RAB9ATP53MAPTLMNA | |
| SCHEMBL18590274 | 0.76 | HDAC4 (0.62) | NPC1RAB9ATP53MAPTLMNA | |
| SCHEMBL2360965 | 0.76 | NPC1 (0.51) | NPC1RAB9ATP53MAPTHTT | |
| SCHEMBL2359855 | 0.76 | NOTUM (0.56) | NPC1RAB9ATSHRHTTL3MBTL1 | |
| SCHEMBL5661093 | 0.75 | RAB9A (0.61) | NPC1RAB9ATP53MAPTLMNA | |
| SCHEMBL2094785 | 0.75 | NR1H4 (0.63) | NPC1RAB9ATP53MAPTTSHR | |
| SCHEMBL23490198 | 0.75 | NPC1 (0.61) | NPC1RAB9ATP53MAPTLMNA | |
| SCHEMBL95162 | 0.75 | RAB9A (0.64) | NPC1RAB9ATP53MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5670526-A | ANTIINFLAMMATORY AGENT, IMMUNOSUPPRESSANT | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-23 | — | — | US | disclosed |