SCHEMBL2360965

SCHEMBL2360965

[CH2]c1nc(-c2ccc(F)cc2)no1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 6/20 0.51
RAB9A P51151 5/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
HTT P42858 1/20 0.51
SIRT2 Q8IXJ6 1/20 0.50
CASP3 P42574 3/20 0.49
SENP8 Q96LD8 3/20 0.49
SENP7 Q9BQF6 3/20 0.49
TP53 P04637 2/20 0.45
SENP6 Q9GZR1 2/20 0.45
MAPT P10636 3/20 0.44
ATM Q13315 1/20 0.42
HDAC1 Q13547 3/20 0.42
HDAC6 Q9UBN7 3/20 0.42
HDAC8 Q9BY41 3/20 0.42
HDAC4 P56524 2/20 0.41
TPH1 P17752 2/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
PSMD11 O00231 1/20 0.41
HDAC2 Q92769 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2359855 0.80 NOTUM (0.56) NPC1RAB9ASMN1; SMN2HTTSIRT2
SCHEMBL2094785 0.79 NR1H4 (0.63) NPC1RAB9ASMN1; SMN2HTTCASP3
SCHEMBL2360818 0.78 TP53 (0.56) NPC1RAB9ASMN1; SMN2CASP3SENP7
SCHEMBL6367494 0.78 NPC1 (0.53) NPC1RAB9ASMN1; SMN2HTTSIRT2
SCHEMBL24061386 0.76 NOTUM (0.66) NPC1RAB9ASMN1; SMN2HTTSIRT2
SCHEMBL2360966 0.76 L3MBTL1 (0.58) NPC1RAB9ASMN1; SMN2HTTSIRT2
SCHEMBL5661093 0.76 RAB9A (0.61) NPC1RAB9ASMN1; SMN2HTTSIRT2
SCHEMBL8830004 0.76 NPC1 (0.59) NPC1RAB9ASMN1; SMN2HTTTP53
SCHEMBL6367462 0.76 CASP3 (0.60) NPC1RAB9ASMN1; SMN2HTTSIRT2
SCHEMBL3059321 0.73 NR1H4 (0.78) NPC1RAB9ASMN1; SMN2CASP3SENP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2393809-B1 DERIVATIVES OF AZASPIRANYL-ALKYLCARBAMATES OF 5-MEMBER HETEROCYCLIC COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI SA (FR) 2014-04-30 EP claimed
EP-2393809-A2 DERIVATIVES OF AZASPIRANYL-ALKYLCARBAMATES OF 5-MEMBER HETEROCYCLIC COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI (FR) 2011-12-14 EP claimed
WO-2010089510-A2 DERIVATIVES OF AZASPIRANYL-ALKYLCARBAMATES OF 5-MEMBER HETEROCYCLIC COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2010-08-12 WO claimed
EP-2356108-B1 CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI SA (FR) 2014-10-15 EP disclosed
EP-2393809-B1 DERIVATIVES OF AZASPIRANYL-ALKYLCARBAMATES OF 5-MEMBER HETEROCYCLIC COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI SA (FR) 2014-04-30 EP disclosed
EP-2393809-A2 DERIVATIVES OF AZASPIRANYL-ALKYLCARBAMATES OF 5-MEMBER HETEROCYCLIC COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI (FR) 2011-12-14 EP disclosed
EP-2356108-A1 CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI (FR) 2011-08-17 EP disclosed
WO-2010089510-A2 DERIVATIVES OF AZASPIRANYL-ALKYLCARBAMATES OF 5-MEMBER HETEROCYCLIC COMPOUNDS, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2010-08-12 WO disclosed
WO-2010055267-A1 CARBAMATE DERIVATIVES OF ALKYL-HETEROCYCLES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2010-05-20 WO disclosed