Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | PPP3CB | P16298 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1101734 | 0.94 | CTSS (0.44) | CTSSUCHL1CTSBPPP3CBADRB3 | |
| SCHEMBL7936436 | 0.94 | CTSS (0.44) | CTSSUCHL1CTSBPPP3CBADRB3 | |
| SCHEMBL1101688 | 0.93 | CTSS (0.44) | CTSSUCHL1CTSBPPP3CBADRB3 | |
| SCHEMBL12775112 | 0.86 | UCHL1 (0.38) | CTSSUCHL1CTSBPPP3CBADRB3 | |
| SCHEMBL313204 | 0.86 | UCHL1 (0.38) | CTSSUCHL1CTSBPPP3CBPDE4B | |
| SCHEMBL1101736 | 0.86 | UCHL1 (0.38) | CTSSUCHL1CTSBPPP3CBPDE4B | |
| SCHEMBL2213932 | 0.86 | UCHL1 (0.38) | CTSSUCHL1CTSBPPP3CBPDE4B | |
| SCHEMBL312697 | 0.85 | CTSS (0.38) | CTSSUCHL1CTSBPPP3CBPDE4B | |
| SCHEMBL312698 | 0.85 | CTSS (0.38) | CTSSUCHL1CTSBPPP3CBPDE4B | |
| SCHEMBL882935 | 0.85 | CTSS (0.39) | CTSSPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012040242-A1 | SUBSTITUTED PROLINE INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2012-03-29 | — | — | WO | disclosed |