Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | HPD | P32754 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8830647 | 0.91 | PTGS1 (0.39) | PTGS1PTGS2ADORA2AADORA2BTNKS | |
| SCHEMBL8830563 | 0.91 | PTGS1 (0.40) | PTGS1PTGS2ADORA2AADORA2BALDH1A1 | |
| SCHEMBL8830565 | 0.89 | ADORA2B (0.41) | PTGS1PTGS2ADORA2BALDH1A1 | |
| SCHEMBL8830678 | 0.84 | ADORA2A (0.47) | ADORA2AADORA2B | |
| SCHEMBL8830550 | 0.81 | KDM4E (0.36) | ADORA2AADORA2BALDH1A1HPD | |
| SCHEMBL8830751 | 0.78 | KMT2A (0.41) | ADORA2AADORA2BALDH1A1 | |
| SCHEMBL8830603 | 0.76 | KDM4E (0.41) | ADORA2AADORA2BALDH1A1 | |
| SCHEMBL8830649 | 0.75 | ADORA2A (0.47) | ADORA2AADORA2B | |
| SCHEMBL8830564 | 0.74 | ADORA2B (0.53) | ADORA2AADORA2BALDH1A1 | |
| SCHEMBL8830571 | 0.73 | ADORA2B (0.56) | ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5661153-A | FOR TREATING ALLERGIES, ASTHMA, DERMATITIS, GRAFT REJECTIONS | JAPAN ENERGY CORPORATION (JP) | 1997-08-26 | — | — | US | disclosed |
| EP-0700908-A1 | 1-Arylpyrimidine derivatives and pharmaceutical use thereof | JAPAN ENERGY CORPORATION (JP) | 1996-03-13 | — | — | EP | disclosed |