Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8830851 | 0.89 | BACE1 (0.41) | MCHR1ABCG2MAPK1SMN1; SMN2TP53 | |
| SCHEMBL8788717 | 0.85 | ABCG2 (0.57) | BCHEACHEOPRM1TMEM97SIGMAR1 | |
| SCHEMBL8790357 | 0.85 | ABCG2 (0.54) | MCHR1BCHEACHEOPRM1TMEM97 | |
| SCHEMBL8789798 | 0.84 | ABCG2 (0.48) | MCHR1BCHEACHEOPRM1TMEM97 | |
| SCHEMBL8790077 | 0.83 | ABCG2 (0.47) | MCHR1BCHEACHEOPRM1TMEM97 | |
| SCHEMBL8789078 | 0.83 | ABCG2 (0.47) | MCHR1BCHEACHEOPRM1TMEM97 | |
| SCHEMBL8830855 | 0.82 | ABCG2 (0.37) | MCHR1ABCG2MAPK1SMN1; SMN2POLB | |
| SCHEMBL8789139 | 0.82 | ABCG2 (0.58) | BCHEACHEOPRM1TMEM97SIGMAR1 | |
| SCHEMBL8809362 | 0.81 | SMN1; SMN2 (0.43) | MCHR1BCHEACHEOPRM1TMEM97 | |
| SCHEMBL8815851 | 0.78 | BCHE (0.43) | MCHR1BCHEACHEABCG2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |