Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.35 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8830851 | 0.83 | BACE1 (0.41) | ABCG2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL8830849 | 0.82 | MCHR1 (0.42) | ABCG2MAPTKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL8809375 | 0.80 | MAPT (0.39) | MAPTKDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8815867 | 0.78 | MEN1 (0.38) | ABCG2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL8808228 | 0.74 | ABCG2 (0.43) | ABCG2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL8807874 | 0.74 | ABCG2 (0.43) | ABCG2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL8809008 | 0.73 | MAPT (0.39) | ABCG2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL8789610 | 0.70 | ABCG2 (0.66) | ABCG2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL8790088 | 0.70 | ABCG2 (0.53) | ABCG2MAPTMEN1KMT2AABCB1 | |
| SCHEMBL8808377 | 0.70 | MAPT (0.40) | MAPTKDM4EMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663179-A | CAN SENSITIZE MULTIDRUG RESISTANT CANCER CELLS TO CHEMOTHERAPEUTIC AGENTS | LABORATOIRES GLAXO SA (FR) | 1997-09-02 | — | — | US | disclosed |