Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.48 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.48 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL8830859 | 0.98 | GLRA1 (0.46) | GLRA1SLC6A9OR51E2HTTATM | |
| Succinic Acid SCHEMBL5403541 | 0.86 | ATM (0.44) | HTTATMDPP7ALDH1A1F2 | |
| Beta-Alanine SCHEMBL9092097 | 0.85 | ATM (0.40) | HTTATMDPP7ALDH1A1SMN1; SMN2 | |
| SCHEMBL1363715 | 0.84 | — | — | |
| SCHEMBL302276 | 0.84 | — | — | |
| Succinic Acid SCHEMBL5411814 | 0.84 | SMN1; SMN2 (0.47) | HTTATMDPP7ALDH1A1F2 | |
| Beta-Alanine SCHEMBL27722682 | 0.83 | CYP1A2 (0.42) | HTTATMDPP7ALDH1A1F2 | |
| SCHEMBL23963672 | 0.82 | ALDH1A1 (0.55) | HTTATMDPP7ALDH1A1F2 | |
| SCHEMBL2281541 | 0.82 | — | — | |
| SCHEMBL7749269 | 0.82 | ALDH1A1 (0.55) | HTTATMDPP7ALDH1A1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997011080-A1 | SUBSTITUTED THIOL MACROLACTAM IMMUNOMODULATORS | ABBOTT LABORATORIES (US) | 1997-03-27 | — | — | WO | disclosed |
| US-5604234-A | IMMUNOSUPPRESSANTS; TREATING AUTOIMMUNE DISEASES, TRANSPLANT REJECTION | ABBOTT LABORATORIES (US) | 1997-02-18 | — | — | US | disclosed |