Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | DRD2 | P14416 | 4/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 6/20 | 0.48 |
| ▸ | DRD3 | P35462 | 4/20 | 0.48 |
| ▸ | MC4R | P32245 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12798134 | 0.80 | SIGMAR1 (0.55) | SIGMAR1DRD2HTR1AHTR2AHTT | |
| SCHEMBL13959654 | 0.79 | DRD4 (0.56) | SIGMAR1DRD2HTR1AHTR2AHTT | |
| SCHEMBL2395932 | 0.79 | DRD4 (0.67) | SIGMAR1DRD2HTR1AHTR2AHTT | |
| SCHEMBL1076822 | 0.79 | SIGMAR1 (0.53) | SIGMAR1DRD2HTR1AHTR2AHTT | |
| SCHEMBL8831136 | 0.77 | SIGMAR1 (0.52) | SIGMAR1DRD2HTR1AHTR2AHTT | |
| SCHEMBL5242533 | 0.77 | SLC6A4 (0.53) | SIGMAR1DRD2HTR1AHTR2AHTT | |
| SCHEMBL6263887 | 0.77 | SIGMAR1 (0.52) | SIGMAR1DRD2HTR1AHTR2AHTT | |
| Hydrochloric Acid SCHEMBL23882203 | 0.76 | DRD2 (0.50) | SIGMAR1DRD2HTR1AHTR2AHTT | |
| SCHEMBL6585625 | 0.76 | DRD4 (0.63) | SIGMAR1DRD2HTR1AHTR2AHTT | |
| SCHEMBL8984029 | 0.76 | SIGMAR1 (0.50) | SIGMAR1DRD2HTR1AHTR2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3041841-B1 | TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | HOFFMANN LA ROCHE (CH) | 2019-06-05 | — | — | EP | disclosed |
| US-5627169-A | Selective antagonists for GABArho receptor | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-05-06 | — | — | US | disclosed |