SCHEMBL8831355

SCHEMBL8831355

COc1ccc(C=C(C#N)c2c[nH]c3ccccc23)cc1OC

nearest known ligand 0.72

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.72
KMT2A Q03164 3/20 0.72
NPC1 O15118 3/20 0.72
KIF20A O95235 9/20 0.71
POLB P06746 4/20 0.59
SMN1; SMN2 Q16637 2/20 0.59
MAPT P10636 2/20 0.59
DYRK1A Q13627 5/20 0.56
RECQL P46063 1/20 0.55
HIF1A Q16665 1/20 0.55
EGFR P00533 1/20 0.55
PDGFRB P09619 1/20 0.55
PDGFRA P16234 1/20 0.55
CLK1 P49759 4/20 0.51
ALDH1A1 P00352 1/20 0.51
RAB9A P51151 2/20 0.49
PKM P14618 1/20 0.49
USP2 O75604 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8831354 1.00 MEN1 (0.72) MEN1KMT2ANPC1KIF20APOLB
SCHEMBL15904682 0.83 KIF20A (0.82) MEN1KMT2ANPC1KIF20APOLB
SCHEMBL15904684 0.83 KIF20A (0.82) MEN1KMT2ANPC1KIF20APOLB
SCHEMBL2724567 0.83 KIF20A (1.00) MEN1KMT2ANPC1KIF20APOLB
SCHEMBL2724561 0.83 KIF20A (1.00) MEN1KMT2ANPC1KIF20APOLB
SCHEMBL19192415 0.80 KIF20A (0.75) MEN1KMT2ANPC1KIF20APOLB
SCHEMBL19193662 0.80 KIF20A (0.89) MEN1KMT2ANPC1KIF20APOLB
SCHEMBL274836 0.79 KIF20A (0.79) MEN1KMT2ANPC1KIF20ADYRK1A
SCHEMBL274837 0.79 KIF20A (0.79) MEN1KMT2ANPC1KIF20ADYRK1A
SCHEMBL17207498 0.79 KIF20A (0.65) MEN1KMT2ANPC1KIF20APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5677329-A ANTAGONIST TO EPIDERMAL GROWTH FACTOR RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) 1997-10-14 US claimed
EP-0525109-A4 STYRYL-SUBSTITUTED MONOCYCLIC AND BICYCLIC HETEROARYL COMPOUNDS WHICH INHIBIT EGF RECEPTOR TYROSINE KINASE 1993-06-30 EP claimed
EP-0525109-A1 STYRYL-SUBSTITUTED MONOCYCLIC AND BICYCLIC HETEROARYL COMPOUNDS WHICH INHIBIT EGF RECEPTOR TYROSINE KINASE RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) 1993-02-03 EP claimed
WO-1991016051-A1 STYRYL-SUBSTITUTED MONOCYCLIC AND BICYCLIC HETEROARYL COMPOUNDS WHICH INHIBIT EGF RECEPTOR TYROSINE KINASE RHÔNE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) 1991-10-31 WO claimed
US-5677329-A ANTAGONIST TO EPIDERMAL GROWTH FACTOR RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) 1997-10-14 US disclosed
US-5597837-A Method and composition for treating psoriasis with styryl-substituted pyridyl compounds Rh one-Poulenc Rorer Pharmaceuticals Inc. (US) 1997-01-28 US disclosed
US-5302606-A Administering to inhibit cell proliferation RHONE-POULENC RORER PHARMACEUTICALS INC. (US) 1994-04-12 US disclosed
EP-0525109-A4 STYRYL-SUBSTITUTED MONOCYCLIC AND BICYCLIC HETEROARYL COMPOUNDS WHICH INHIBIT EGF RECEPTOR TYROSINE KINASE 1993-06-30 EP disclosed
EP-0525109-A1 STYRYL-SUBSTITUTED MONOCYCLIC AND BICYCLIC HETEROARYL COMPOUNDS WHICH INHIBIT EGF RECEPTOR TYROSINE KINASE RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) 1993-02-03 EP disclosed
WO-1991016051-A1 STYRYL-SUBSTITUTED MONOCYCLIC AND BICYCLIC HETEROARYL COMPOUNDS WHICH INHIBIT EGF RECEPTOR TYROSINE KINASE RHÔNE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) 1991-10-31 WO disclosed