Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 9/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.31 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.31 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL883189 | 1.00 | PIK3CA (0.38) | PIK3CAPIK3CBPIK3CDPIK3CGPI4KB | |
| SCHEMBL18675245 | 0.78 | FAP (0.51) | PIK3CAPIK3CBPIK3CDPIK3CGPI4KB | |
| SCHEMBL12943482 | 0.77 | PIK3CA (0.39) | PIK3CAPIK3CBPIK3CDPIK3CGPI4KB | |
| SCHEMBL883054 | 0.76 | MEN1 (0.48) | PIK3CAPIK3CBPIK3CDPIK3CGPI4KB | |
| SCHEMBL22802727 | 0.75 | DPP4 (0.37) | DPP4SMN1; SMN2 | |
| SCHEMBL18771284 | 0.75 | PIK3CA (0.36) | PIK3CAPIK3CBPIK3CDPIK3CGPI4KB | |
| SCHEMBL18098495 | 0.74 | DPP4 (0.31) | DPP4 | |
| SCHEMBL17188728 | 0.72 | DPP4 (0.44) | DPP4 | |
| SCHEMBL18779110 | 0.72 | DPP4 (0.44) | DPP4 | |
| SCHEMBL25807330 | 0.72 | CCR2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012040242-A1 | SUBSTITUTED PROLINE INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2012-03-29 | — | — | WO | disclosed |