Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ECE1 | P42892 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 6/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8833609 | 0.90 | ECE1 (0.38) | KMT2AECE1ABCB1CHRM1 | |
| SCHEMBL9025780 | 0.85 | ECE1 (0.37) | KMT2AECE1ABCB1CHRM1 | |
| SCHEMBL9025782 | 0.85 | ECE1 (0.37) | KMT2AECE1ABCB1CHRM1 | |
| SCHEMBL8832778 | 0.85 | ECE1 (0.36) | KMT2ATDP1ECE1ABCB1CHRM1 | |
| SCHEMBL8833492 | 0.84 | ECE1 (0.37) | KMT2AECE1CHRNB2CHRNA4CHRM1 | |
| SCHEMBL9215980 | 0.84 | ECE1 (0.37) | KMT2AECE1CHRNB2CHRNA4CHRM1 | |
| SCHEMBL9027724 | 0.83 | ECE1 (0.37) | KMT2AECE1ABCB1CHRM1 | |
| SCHEMBL9027719 | 0.83 | ECE1 (0.37) | KMT2AECE1ABCB1CHRM1 | |
| SCHEMBL9026112 | 0.83 | ECE1 (0.36) | KMT2AECE1CHRM1 | |
| SCHEMBL9027798 | 0.83 | ECE1 (0.36) | KMT2AECE1CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5608056-A | Substituted 3-pyrrolidinylthio-carbapenems as antimicrobial agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| EP-0636133-A1 | SUBSTITUTED 3-PYRROLIDINYLTHIO-CARBAPENEMS AS ANTIMICROBIAL AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021186-A1 | SUBSTITUTED 3-PYRROLIDINYLTHIO-CARBAPENEMS AS ANTIMICROBIAL AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-10-28 | — | — | WO | disclosed |