SCHEMBL883366

SCHEMBL883366

O=C(O)CNc1cccc(C(F)(F)F)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.59
MEN1 O00255 3/20 0.59
KMT2A Q03164 3/20 0.59
HTT P42858 2/20 0.59
RAB9A P51151 1/20 0.59
ALDH1A1 P00352 6/20 0.56
L3MBTL1 Q9Y468 2/20 0.56
XBP1 P17861 2/20 0.55
GAA P10253 1/20 0.55
NPSR1 Q6W5P4 1/20 0.55
GRK2 P25098 1/20 0.53
CA12 O43570 1/20 0.53
CA1 P00915 1/20 0.53
CA2 P00918 1/20 0.53
CA4 P22748 1/20 0.53
CA9 Q16790 1/20 0.53
LMNA P02545 2/20 0.53
TP53 P04637 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.52
MAPK1 P28482 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27863512 0.89 MAPT (0.55) MAPTMEN1KMT2AHTTRAB9A
SCHEMBL965055 0.85 ALDH1A1 (0.57) MAPTMEN1KMT2AHTTRAB9A
SCHEMBL1451069 0.85 MAPT (0.58) MAPTMEN1KMT2AHTTRAB9A
Hydrochloric Acid SCHEMBL9738365 0.84 MAPT (0.53) MAPTMEN1KMT2AHTTRAB9A
SCHEMBL14065404 0.83 HDAC8 (0.50) ALDH1A1CA12CA1CA2CA4
SCHEMBL30366730 0.83 ALDH1A1 (0.61) MAPTMEN1KMT2AHTTRAB9A
SCHEMBL9584096 0.83 SMN1; SMN2 (0.59) MAPTMEN1KMT2AHTTRAB9A
SCHEMBL10382109 0.83 MAPT (0.54) MAPTMEN1KMT2AHTTRAB9A
SCHEMBL1441279 0.82 LMNA (0.57) MAPTALDH1A1LMNA
SCHEMBL340537 0.82 AKR1C3 (0.55) MAPTMEN1KMT2AALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 136 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024130161-A2 NOVEL CAMPTOTHECIN DERIVATIVES AND CONJUGATES THEREOF BIONECURE THERAPEUTICS INC (US) 2024-06-20 WO disclosed
US-20240034753-A1 THERAPEUTIC PEPTIDES COHBAR, INC. 2024-02-01 US disclosed
US-11753445-B2 Therapeutic peptides COHBAR, INC. (US) 2023-09-12 US disclosed
US-20230218710-A1 METHOD OF TREATING CORONAVIRUS INFECTIONS COHBAR, INC. 2023-07-13 US disclosed
US-20230137562-A1 TAU AGGREGATION INHIBITORS ADRX, INC. 2023-05-04 US disclosed
EP-4135738-A2 METHOD OF TREATING CORONAVIRUS INFECTIONS Cohbar Inc. (US) 2023-02-22 EP disclosed
US-20220395553-A1 CXCR4 ANTAGONIST PEPTIDES COHBAR, INC. 2022-12-15 US disclosed
US-20220332774-A1 THERAPEUTIC MITOCHONDRIAL PEPTIDES COHBAR, INC. 2022-10-20 US disclosed
US-20220324909-A1 THERAPEUTIC PEPTIDES COHBAR, INC. 2022-10-13 US disclosed
US-20220324925-A1 THERAPEUTIC PEPTIDES COHBAR, INC. 2022-10-13 US disclosed
US-20040014082-A1 Highly homogeneous molecular markers for electrophoresis INVITROGEN CORPORATION 2004-01-22 US disclosed
US-6566338-B1 Administering caspase inhibitor for therapy of oral mucositis, gastrointestinal mucositis, bladder mucositis or proctitis resulting from chemotherapy or radiation therapy of cancer in an animal CYTOVIA, INC. 2003-05-20 US disclosed
EP-1076563-A4 DIPEPTIDE CASPASE INHIBITORS AND THE USE THEREOF CYTOVIA INC (US) 2003-04-23 EP disclosed
US-20020155455-A1 Highly homogeneous molecular markers for electrophoresis INVITROGEN CORPORATION 2002-10-24 US disclosed
EP-1220869-A1 CASPASE INHIBITORS FOR THE TREATMENT AND PREVENTION OF CHEMOTHERAPY AND RADIATION THERAPY INDUCED CELL DEATH Cytovia, Inc. (US) 2002-07-10 EP disclosed
CN-1297354-A Dipeptide caspase inhibitors and use thereof CYTOVIA INC (US) 2001-05-30 CN disclosed
WO-2001027140-A1 CASPASE INHIBITORS FOR THE TREATMENT AND PREVENTION OF CHEMOTHERAPY AND RADIATION THERAPY INDUCED CELL DEATH CYTOVIA, INC. (US) 2001-04-19 WO disclosed
EP-1076563-A1 DIPEPTIDE CASPASE INHIBITORS AND THE USE THEREOF Cytovia, Inc. (US) 2001-02-21 EP disclosed
US-6153591-A PROTECTING NERVOUS SYSTEM FOLLOWING FOCAL ISCHEMIA AND GLOBAL ISCHEMIA; ALZHEIMER'S DISEASE, HUNTINGTON'S DISEASE, PRION DISEASES, PARKINSON'S DISEASE, MULTIPLE SCLEROSIS, AMYOTROPHIC LATERAL SCLEROSIS, ALOPACIA, RHEUMATOID ARTHRITIS CYTOVIA, INC. (US) 2000-11-28 US disclosed
WO-1999047154-A1 DIPEPTIDE CASPASE INHIBITORS AND THE USE THEREOF CYTOVIA, INC. (US) 1999-09-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040014082-A1 Highly homogeneous molecular markers for electrophoresis CD44, HLA-C, HLA-A MAPT 3603/4885MEN1 4311/4885KMT2A 3634/4885
US-20020155455-A1 Highly homogeneous molecular markers for electrophoresis CD44, HLA-C, HLA-A MAPT 3603/4885MEN1 4311/4885KMT2A 3634/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.