Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK10 | O94804 | 2/20 | 0.61 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.61 |
| ▸ | EGFR | P00533 | 3/20 | 0.59 |
| ▸ | SRC | P12931 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RGS12 | O14924 | 1/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PRKCG | P05129 | 1/20 | 0.45 |
| ▸ | PRKCB | P05771 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8834532 | 0.91 | EGFR (0.76) | STK10SLKEGFRSRCGAA | |
| SCHEMBL8834725 | 0.81 | STK10 (0.61) | STK10SLKEGFRSRCGAA | |
| SCHEMBL5814108 | 0.80 | EGFR (0.88) | STK10SLKEGFRSRCGAA | |
| SCHEMBL8835073 | 0.76 | EGFR (0.72) | STK10SLKEGFRSRCGAA | |
| SCHEMBL8833729 | 0.75 | EGFR (1.00) | STK10SLKEGFRSRCGAA | |
| SCHEMBL383690 | 0.75 | MAOA (0.59) | EGFRSRCALDH1A1MEN1KMT2A | |
| SCHEMBL8834581 | 0.74 | EGFR (0.66) | STK10SLKEGFRSRCALDH1A1 | |
| SCHEMBL8833563 | 0.74 | EGFR (0.61) | STK10SLKEGFRSRCALDH1A1 | |
| SCHEMBL8833701 | 0.74 | GAA (0.62) | GAAALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL8834053 | 0.74 | AKR1C3 (0.63) | GAAALDH1A1HPGDMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663336-A | IMIDATION OF DIAMINOPHTHALIC ACID TO FORM KINASE INHIBITORS AS ANTITUMOR AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-09-02 | — | — | US | disclosed |
| US-5491144-A | KINASE INHIBITORS, ANTITUMOR AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-02-13 | — | — | US | disclosed |