SCHEMBL883512

SCHEMBL883512

COc1ccc2c(c1)CCn1c-2cc(OCCc2ccc(Oc3ccc(Cl)c(C(F)(F)F)c3)c(C#N)c2)nc1=O

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PLA2G7 Q13093 2/20 0.55
GPR84 Q9NQS5 18/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10246091 0.93 PLA2G7 (0.63) PLA2G7GPR84
SCHEMBL876632 0.93 PLA2G7 (0.54) PLA2G7GPR84
SCHEMBL16199423 0.90 GPR84 (0.52) GPR84
SCHEMBL878366 0.89 GPR84 (0.58) PLA2G7GPR84
SCHEMBL883810 0.89 GPR84 (0.56) GPR84
SCHEMBL10245418 0.89 GPR84 (0.53) GPR84
SCHEMBL877316 0.88 PLA2G7 (0.63) PLA2G7GPR84
SCHEMBL878242 0.88 GPR84 (0.53) GPR84
SCHEMBL878192 0.87 GPR84 (0.51) GPR84
SCHEMBL877801 0.86 GPR84 (0.55) PLA2G7GPR84

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012037782-A1 TRICYCLIC COMPOUNDS, PREPARATION METHODS, AND THEIR USES GLAXO GROUP LIMITED (GB) 2012-03-29 WO disclosed