Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 8/20 | 0.53 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | PPIA | P62937 | 1/20 | 0.47 |
| ▸ | F9 | P00740 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10681378 | 0.85 | ABCG2 (0.50) | ABCG2SYKEGLN1EGFR | |
| SCHEMBL10675934 | 0.82 | AURKA (0.42) | ABCG2SYKGRM4PPIA | |
| SCHEMBL9402399 | 0.79 | NPC1 (0.56) | ABCG2SYKGRM4EGFR | |
| SCHEMBL10094598 | 0.79 | EGFR (0.53) | ABCG2SYKGRM4F9EGFR | |
| SCHEMBL9402412 | 0.79 | GRM4 (0.52) | ABCG2GRM4EGFR | |
| SCHEMBL6797398 | 0.79 | ABCG2 (0.56) | ABCG2SYKGRM4PPIAF9 | |
| SCHEMBL10672819 | 0.79 | LMNA (0.59) | ABCG2SYKGRM4EGFR | |
| SCHEMBL9402336 | 0.78 | GRM4 (0.50) | ABCG2GRM4EGFR | |
| SCHEMBL9402414 | 0.78 | GRM4 (0.51) | GRM4 | |
| SCHEMBL1375014 | 0.78 | DHODH (0.56) | ABCG2GRM4EGFRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663181-A | Naphthyridine derivatives, their methods of preparation and pharmaceutical compositions in which they are present, useful especially as antiproliferative drugs | LABORATOIRES UPSA (FR) | 1997-09-02 | — | — | US | disclosed |
| CN-1125444-A | Naphthyridine derivatives, process for their preparation and pharmaceutical compositions containing them, especially useful as antiproliferative agents | UNION PHARMA SCIENT APPL (FR) | 1996-06-26 | — | — | CN | disclosed |
| EP-0705261-A1 | ANTIPROLIFERATIVE NAPHTHYRIDINES | LABORATOIRES UPSA (FR) | 1996-04-10 | — | — | EP | disclosed |
| WO-1995000513-A1 | ANTIPROLIFERATIVE NAPHTHYRIDINES | LABORATOIRES UPSA (FR) | 1995-01-05 | — | — | WO | disclosed |
| US-5364860-A | Naphthyridine compounds which inhibit tyrosine kinase and their pharmaceutical compositions | LABORATOIRES UPSA (FR) | 1994-11-15 | — | — | US | disclosed |
| US-4786642-A | ANTIULCER | SOCIETE ANONYME: CARPIBEM (FR) | 1988-11-22 | — | — | US | disclosed |