Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 2/20 | 0.54 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 3/20 | 0.40 |
| ▸ | SQOR | Q9Y6N5 | 2/20 | 0.40 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8836756 | 0.81 | MAPK14 (0.50) | TDO2MAPK14FLT3CYP1A2ALDH1A1 | |
| SCHEMBL31039970 | 0.75 | TGFBR1 (0.59) | TGFBR1MAPK14LMNAMAPTMEN1 | |
| SCHEMBL7496200 | 0.74 | MAPK14 (0.58) | TDO2MAPK14 | |
| SCHEMBL29638126 | 0.74 | TGFBR1 (0.57) | TGFBR1MAPK14LMNAMEN1KMT2A | |
| SCHEMBL1358217 | 0.74 | TGFBR1 (0.57) | TGFBR1MAPK14LMNAMEN1KMT2A | |
| SCHEMBL8836231 | 0.73 | TDO2 (0.45) | TDO2TGFBR1MAPK14MAPTGRM5 | |
| SCHEMBL28732654 | 0.73 | TGFBR1 (0.56) | TGFBR1MAPK14LMNAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL29604167 | 0.73 | TGFBR1 (0.56) | TGFBR1MAPK14LMNAMEN1KMT2A | |
| SCHEMBL29728520 | 0.73 | TGFBR1 (0.56) | TGFBR1MAPK14LMNAMEN1KMT2A | |
| SCHEMBL26819497 | 0.73 | TGFBR1 (0.56) | TGFBR1MAPK14LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5624931-A | Pyrazole derivatives | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-29 | — | — | US | disclosed |
| US-5478827-A | Inhibits Interleukin-1 and tumor necrosis factor production | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-12-26 | — | — | US | disclosed |
| EP-0531901-A2 | Condensed pyrazole derivatives with interleukin-1 and tumour necrosis factor inhibitory activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-03-17 | — | — | EP | disclosed |