Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 13/20 | 0.60 |
| ▸ | SLC6A3 known ✓ | Q01959 | 13/20 | 0.60 |
| ▸ | SLC6A4 known ✓ | P31645 | 5/20 | 0.60 |
| ▸ | CHRNB2 | P17787 | 13/20 | 0.60 |
| ▸ | CHRNB4 | P30926 | 13/20 | 0.60 |
| ▸ | CHRNA3 | P32297 | 13/20 | 0.60 |
| ▸ | CHRNA4 | P43681 | 13/20 | 0.60 |
| ▸ | CHRNA1 | P02708 | 12/20 | 0.60 |
| ▸ | CHRNB1 | P11230 | 12/20 | 0.60 |
| ▸ | CHRNG | P07510 | 11/20 | 0.44 |
| ▸ | CHRND | Q07001 | 11/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8665450 | 1.00 | CHRNB2 (0.60) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| Bromide SCHEMBL8665453 | 1.00 | CHRNB2 (0.60) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| Manifaxine SCHEMBL9697412 | 0.87 | CHRNB2 (0.57) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| Manifaxine SCHEMBL9696223 | 0.87 | CHRNB2 (0.57) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| Manifaxine SCHEMBL9697408 | 0.87 | CHRNB2 (0.57) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| Manifaxine SCHEMBL9695101 | 0.87 | CHRNB2 (0.57) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| Manifaxine SCHEMBL2633826 | 0.85 | CHRNB2 (0.58) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| Manifaxine SCHEMBL9696551 | 0.85 | CHRNB2 (0.58) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| Manifaxine SCHEMBL7775056 | 0.85 | CHRNB2 (0.58) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| Manifaxine SCHEMBL2954001 | 0.85 | CHRNB2 (0.58) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5648347-A | ANTIDEPRESSANTS | GLAXO WELLCOME INC. (US) | 1997-07-15 | — | — | US | disclosed |