Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7820263 | 0.84 | KCNH2 (0.67) | KCNH2ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL7089743 | 0.74 | KCNH2 (0.64) | KCNH2ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL3488453 | 0.73 | PSEN1 (0.41) | KCNH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7087129 | 0.73 | KCNH2 (1.00) | KCNH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7092063 | 0.73 | KCNH2 (0.65) | KCNH2ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL7090700 | 0.73 | KCNH2 (1.00) | KCNH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7207237 | 0.71 | KCNH2 (0.69) | KCNH2ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL8618901 | 0.71 | ALDH1A1 (0.48) | KCNH2ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL7090513 | 0.70 | KCNH2 (0.81) | KCNH2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8761589 | 0.70 | KCNH2 (0.80) | KCNH2PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5597818-A | CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1997-01-28 | — | — | US | disclosed |