Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8608963 | 0.81 | KCNH2 (0.60) | ALDH1A1MEN1KMT2ATDP1HTT | |
| SCHEMBL7090394 | 0.81 | KCNH2 (0.60) | ALDH1A1MEN1KMT2ATDP1HTT | |
| SCHEMBL7090389 | 0.81 | KCNH2 (0.60) | ALDH1A1MEN1KMT2ATDP1HTT | |
| SCHEMBL7820263 | 0.74 | KCNH2 (0.67) | ALDH1A1MEN1KMT2ATDP1HTT | |
| SCHEMBL8608811 | 0.74 | KCNH2 (0.59) | ALDH1A1MEN1KMT2ATDP1HTT | |
| SCHEMBL8713101 | 0.74 | KCNH2 (0.59) | ALDH1A1MEN1KMT2ATDP1HTT | |
| SCHEMBL8801265 | 0.72 | KCNH2 (0.56) | ALDH1A1MEN1KMT2ATDP1HTT | |
| SCHEMBL8801258 | 0.72 | KCNH2 (0.56) | ALDH1A1MEN1KMT2ATDP1HTT | |
| SCHEMBL7213180 | 0.71 | KCNH2 (0.63) | ALDH1A1MEN1KMT2ATDP1HTT | |
| SCHEMBL8837495 | 0.71 | KCNH2 (0.57) | ALDH1A1MEN1KMT2ATDP1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730453-A4 | METHODS OF TREATING CARDIAC ARRHYTHMIA | MERCK & CO INC (US) | 1998-03-04 | — | — | EP | disclosed |
| WO-1997049690-A1 | A METHOD FOR TREATING MENIERE'S DISEASE | MERCK & CO., INC. (US) | 1997-12-31 | — | — | WO | disclosed |
| EP-0730453-A1 | METHODS OF TREATING CARDIAC ARRHYTHMIA | MERCK & CO. INC. (US) | 1996-09-11 | — | — | EP | disclosed |
| WO-1995014470-A1 | METHODS OF TREATING CARDIAC ARRHYTHMIA | MERCK & CO., INC. (US) | 1995-06-01 | — | — | WO | disclosed |