Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.34 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL803714 | 0.85 | GAA (0.40) | GAANFKB1NFKB2RELARORC | |
| SCHEMBL785315 | 0.84 | RORC (0.42) | GAANFKB1NFKB2RELARORC | |
| Acetic Acid SCHEMBL28780395 | 0.84 | GAA (0.40) | GAANFKB1NFKB2RELAPARP1 | |
| SCHEMBL785741 | 0.83 | GAA (0.41) | GAANFKB1NFKB2RELARORC | |
| SCHEMBL785742 | 0.83 | GAA (0.41) | GAANFKB1NFKB2RELARORC | |
| SCHEMBL19961240 | 0.81 | CYP11B1 (0.41) | GAANFKB1NFKB2RELAPARP1 | |
| SCHEMBL12656485 | 0.75 | CA12 (0.43) | GAANFKB1NFKB2RELAEPHX2 | |
| SCHEMBL8224196 | 0.74 | GAA (0.39) | GAANFKB1NFKB2RELAEPHX2 | |
| SCHEMBL31730651 | 0.73 | BDKRB1 (0.39) | GAANFKB1NFKB2RELAEPHX2 | |
| SCHEMBL31730587 | 0.73 | AAK1 (0.39) | GAANFKB1NFKB2RELAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038081-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-03-29 | — | — | WO | disclosed |