Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 4/20 | 0.67 |
| ▸ | MME | P08473 | 3/20 | 0.67 |
| ▸ | F7 | P08709 | 3/20 | 0.50 |
| ▸ | F3 | P13726 | 3/20 | 0.50 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | PREP | P48147 | 2/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11067510 | 0.85 | ACE (0.55) | ACEMMEF7F3XIAP | |
| SCHEMBL7864412 | 0.83 | ACE (0.56) | ACEMMEF7F3XIAP | |
| SCHEMBL7864413 | 0.83 | ACE (0.56) | ACEMMEF7F3XIAP | |
| SCHEMBL11061682 | 0.83 | ACE (0.56) | ACEMMEF7F3XIAP | |
| SCHEMBL10855859 | 0.82 | ACE (0.52) | ACEMMEF7F3XIAP | |
| SCHEMBL10855731 | 0.82 | ACE (0.52) | ACEMMEF7F3XIAP | |
| SCHEMBL7349685 | 0.80 | MME (1.00) | ACEMMEXIAP | |
| SCHEMBL7349689 | 0.80 | MME (1.00) | ACEMMEXIAP | |
| SCHEMBL10857935 | 0.77 | ACE (0.67) | ACEMME | |
| SCHEMBL10857940 | 0.77 | ACE (0.67) | ACEMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654294-A | CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB (US) | 1997-08-05 | — | — | US | disclosed |
| US-5646276-A | ANGIOTENSIN CONVERTING ENZYME AND NEUTRAL ENDOPEPTIDASE INHIBITORS; CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5552397-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-09-03 | — | — | US | disclosed |