Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 8/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.34 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.34 |
| ▸ | DUT | P33316 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8500394 | 0.79 | MAPT (0.41) | MAPTSMN1; SMN2ALDH1A1LMNAHPGD | |
| SCHEMBL5469275 | 0.78 | MAPT (0.43) | MAPTKMT2AMEN1MAPK1RECQL | |
| SCHEMBL12594358 | 0.77 | MAPT (0.40) | MAPTKMT2AMEN1MAPK1RECQL | |
| SCHEMBL15038556 | 0.77 | MAPT (0.43) | MAPTKMT2AMEN1MAPK1NPC1 | |
| SCHEMBL5467390 | 0.77 | MAPT (0.44) | MAPTKMT2AMEN1MAPK1RECQL | |
| SCHEMBL15823738 | 0.76 | ALDH1A1 (0.39) | TDP1MAPTKMT2AMEN1MAPK1 | |
| SCHEMBL99653 | 0.76 | ALDH1A1 (0.39) | TDP1MAPTKMT2AMEN1MAPK1 | |
| SCHEMBL5455878 | 0.76 | MAPT (0.55) | MAPTKMT2AMEN1MAPK1NPC1 | |
| SCHEMBL8472445 | 0.76 | CHRNB2 (0.56) | MAPTKMT2AMEN1RAB9AALDH1A1 | |
| SCHEMBL8500377 | 0.76 | MAPT (0.39) | MAPTKMT2AMEN1MAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5614550-A | ANTICHOLESTEROL AGENTS OR ARTERIOSCLEROSIS AGENTS FOR HUMANS | SANKYO COMPANY, LIMITED (JP) | 1997-03-25 | — | — | US | disclosed |
| US-5534529-A | Substituted aromatic amides and ureas derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses | SANKYO COMPANY, LIMITED (JP) | 1996-07-09 | — | — | US | disclosed |
| EP-0632036-A2 | Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1995-01-04 | — | — | EP | disclosed |