SCHEMBL883885

SCHEMBL883885

Cc1noc(C)c1C(=O)N(C)CCc1csc(NC(=O)NCc2ccc(Cl)c(Cl)c2)n1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 2/20 0.45
LMNA P02545 1/20 0.40
THRB P10828 1/20 0.40
CYP1A2 P05177 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
ROCK1 Q13464 7/20 0.39
ROCK2 O75116 6/20 0.39
AURKA O14965 1/20 0.38
DYRK3 O43781 1/20 0.38
PRKD3 O94806 1/20 0.38
PRKCG P05129 1/20 0.38
PRKACA P17612 1/20 0.38
RPS6KB1 P23443 1/20 0.38
MARK3 P27448 1/20 0.38
MAPK1 P28482 1/20 0.38
AKT1 P31749 1/20 0.38
CSNK1D P48730 1/20 0.38
CLK2 P49760 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL353096 0.92 P2RX7 (0.46) P2RX7LMNATHRBCYP1A2CYP2C9
SCHEMBL354314 0.86 P2RX7 (0.44) P2RX7LMNATHRBCYP1A2CYP2C9
SCHEMBL351707 0.86 P2RX7 (0.46) P2RX7LMNATHRBCYP1A2CYP2C9
SCHEMBL354560 0.85 P2RX7 (0.47) P2RX7LMNATHRBCYP1A2CYP2C9
SCHEMBL354369 0.84 P2RX7 (0.44) P2RX7LMNATHRBCYP1A2CYP2C9
SCHEMBL354653 0.83 LMNA (0.46) P2RX7LMNACYP1A2CYP2C9CYP2C19
SCHEMBL352858 0.82 P2RX7 (0.45) P2RX7LMNATHRBROCK1ROCK2
SCHEMBL353398 0.82 P2RX7 (0.40) P2RX7CYP1A2CYP2C9CYP2C19TDP1
SCHEMBL354437 0.81 ROCK1 (0.51) LMNATHRBCYP1A2CYP2C9CYP2C19
SCHEMBL353521 0.81 LMNA (0.39) P2RX7LMNATHRBROCK1ROCK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2200440-A1 ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS Crestone, Inc. (US) 2010-06-30 EP claimed
WO-2009015208-A1 ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS REPLIDYNE, INC. (US) 2009-01-29 WO claimed
EP-2200440-A1 ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS Crestone, Inc. (US) 2010-06-30 EP disclosed
WO-2009015208-A1 ANTIBACTERIAL AMIDE AND SULFONAMIDE SUBSTITUTED HETEROCYCLIC UREA COMPOUNDS REPLIDYNE, INC. (US) 2009-01-29 WO disclosed