SCHEMBL8840221

SCHEMBL8840221

C[C@]12CC[C@@H]3c4ccc(O)cc4CC[C@H]3[C@@H]1CC[C@@H]2C(=O)O

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 6/20 0.71
ESR2 Q92731 5/20 0.71
LMNA P02545 5/20 0.71
HSD17B10 Q99714 3/20 0.71
MEN1 O00255 3/20 0.71
KMT2A Q03164 3/20 0.71
CYP3A4 P08684 3/20 0.71
MAPT P10636 3/20 0.71
HIF1A Q16665 3/20 0.71
STS P08842 3/20 0.71
TSHR P16473 2/20 0.71
RECQL P46063 2/20 0.71
SMN1; SMN2 Q16637 2/20 0.71
CYP2C9 P11712 2/20 0.71
CYP2C19 P33261 2/20 0.71
NR3C1 P04150 2/20 0.71
SHBG P04278 2/20 0.71
PGR P06401 2/20 0.71
SERPINA6 P08185 2/20 0.71
AR P10275 2/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9097615 1.00 ESR1 (0.71) ESR1ESR2LMNAHSD17B10MEN1
SCHEMBL3139258 0.91 LMNA (0.71) ESR1ESR2LMNAHSD17B10MEN1
SCHEMBL8432942 0.91 LMNA (0.71) ESR1ESR2LMNAHSD17B10MEN1
SCHEMBL12793146 0.91 LMNA (0.71) ESR1ESR2LMNAHSD17B10MEN1
SCHEMBL9361836 0.89 SRD5A2 (0.78) ESR1ESR2LMNAHSD17B10MEN1
SCHEMBL8840111 0.88 ESR1 (0.65) ESR1ESR2LMNAHSD17B10MEN1
SCHEMBL8840069 0.88 ESR1 (0.65) ESR1ESR2LMNAHSD17B10MEN1
SCHEMBL8840065 0.88 ESR1 (0.65) ESR1ESR2LMNAHSD17B10MEN1
SCHEMBL11208412 0.88 ESR1 (0.70) ESR1ESR2LMNAHSD17B10MEN1
SCHEMBL6462466 0.87 LMNA (0.73) ESR1ESR2LMNAHSD17B10MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5618806-A STEROID 5ALPHA-REDUCTASE INHIBITOR; USEFUL FOR TREATING BENIGN PROSTATIC HYPERTROPHY, BALDNESS, ACNE, VULGURIS, SEBORRHEA, FEMALE HIRSUTISM, AND PROSTATIC ADENOCARCINOMA SMITHKLINE BEECHAM CORPORATION 1997-04-08 US disclosed
EP-0638090-A4 17-g(a) AND 17-g(b)-SUBSTITUTED ESTRA-1,3,5(10)-TRIENE-3-CARBOXYLIC ACID. SMITHKLINE BEECHAM CORP (US) 1995-10-04 EP disclosed
EP-0651643-A4 17-ALKYLKETONE STEROIDS USEFUL AS 5--g(a)-REDUCTASE INHIBITORS. SMITHKLINE BEECHAM CORP (US) 1995-10-04 EP disclosed
WO-1995021185-A1 ACYL 3-CARBOXY AROMATIC A RING STEROID AS 5-ALPHA REDUCTASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 1995-08-10 WO disclosed
EP-0651643-A1 17-ALKYLKETONE STEROIDS USEFUL AS 5-$g(a)-REDUCTASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 1995-05-10 EP disclosed
EP-0638090-A1 17$g(a) AND 17$g(b)-SUBSTITUTED ESTRA-1,3,5(10)-TRIENE-3-CARBOXYLIC ACID SMITHKLINE BEECHAM CORPORATION (US) 1995-02-15 EP disclosed