Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | RECQL | P46063 | 2/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.71 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.71 |
| ▸ | ESR1 | P03372 | 8/20 | 0.71 |
| ▸ | ESR2 | Q92731 | 6/20 | 0.71 |
| ▸ | MAPT | P10636 | 5/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.71 |
| ▸ | PGR | P06401 | 4/20 | 0.71 |
| ▸ | AR | P10275 | 4/20 | 0.71 |
| ▸ | SHBG | P04278 | 3/20 | 0.71 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.71 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.71 |
| ▸ | SNCA | P37840 | 3/20 | 0.71 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12793146 | 1.00 | LMNA (0.71) | LMNACYP3A4KMT2AMEN1RECQL | |
| SCHEMBL8432942 | 1.00 | LMNA (0.71) | LMNACYP3A4KMT2AMEN1RECQL | |
| SCHEMBL8840221 | 0.91 | ESR1 (0.71) | LMNACYP3A4KMT2AMEN1RECQL | |
| SCHEMBL9097615 | 0.91 | ESR1 (0.71) | LMNACYP3A4KMT2AMEN1RECQL | |
| SCHEMBL14396235 | 0.88 | ESR1 (0.71) | LMNACYP3A4KMT2AMEN1RECQL | |
| SCHEMBL9235891 | 0.88 | SRD5A2 (0.76) | LMNACYP3A4KMT2AMEN1RECQL | |
| SCHEMBL11208412 | 0.88 | ESR1 (0.70) | LMNACYP3A4KMT2AMEN1RECQL | |
| SCHEMBL8434675 | 0.87 | ESR1 (0.69) | LMNACYP3A4KMT2AMEN1RECQL | |
| SCHEMBL8434673 | 0.87 | ESR1 (0.69) | LMNACYP3A4KMT2AMEN1RECQL | |
| SCHEMBL2169796 | 0.87 | ESR1 (0.74) | LMNACYP3A4KMT2AMEN1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6083941-A | TREATMENT OF NEUROPATHIC PAIN, DRUG WITHDRAWAL/DEPENDENCY, EPILEPSY, GLAUCOMA, CHRONIC NEURODEGENERATIVE DISEASES, AMYOTROPHIC LATERAL SCLEROSIS, ANXIETY DISORDERS, BRAIN CELL DEATH, ISCHAEMIA, STROKE, TRAUMA | TRUSTEES OF BOSTON UNIVERSITY (US) | 2000-07-04 | — | — | US | claimed |
| US-20250051387-A1 | STEROID DERIVATIVE REGULATORS, METHOD FOR PREPARING THE SAME, AND USES THEREOF | SHANGHAI HANSOH BIOMEDICAL CO., LTD. (CN) | 2025-02-13 | — | — | US | disclosed |
| US-12139508-B2 | Steroid derivative regulators, method for preparing the same, and uses thereof | JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. (CN) | 2024-11-12 | — | — | US | disclosed |
| CN-114805462-A | Steroid derivative regulator and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2022-07-29 | — | — | CN | disclosed |
| US-11384114-B2 | Polymorphic forms of an oxysterol and methods of making them | WARSAW ORTHOPEDIC, INC. (US) | 2022-07-12 | — | — | US | disclosed |
| CN-114656514-A | Steroid derivative regulator and preparation method and application thereof | 江苏豪森药业集团有限公司 | 2022-06-24 | — | — | CN | disclosed |
| EP-3827833-B1 | METHODS FOR THE SEPARATION AND DETECTION OF AN OXYSTEROL | WARSAW ORTHOPEDIC INC (US) | 2022-06-15 | — | — | EP | disclosed |
| US-11324759-B2 | Oxysterol-statin compounds for bone growth | WARSAW ORTHOPEDIC, INC. (US) | 2022-05-10 | — | — | US | disclosed |
| US-11234991-B2 | Methods for the separation and detection of an oxysterol | WARSAW ORTHOPEDIC, INC. (US) | 2022-02-01 | — | — | US | disclosed |
| US-20210238218-A1 | COMPOUNDS AND METHODS OF MAKING STEROLS USING DIOLS | WARSAW ORTHOPEDIC INC (US) | 2021-08-05 | — | — | US | disclosed |
| EP-1405860-B1 | Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use | STANFORD RES INST INT (US) | 2007-02-14 | — | — | EP | disclosed |
| EP-1405860-A1 | Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use | SRI INTERNATIONAL (US) | 2004-04-07 | — | — | EP | disclosed |
| EP-1042354-A2 | ESTRONE SULFAMATE INHIBITORS OF ESTRONE SULFATASE, AND ASSOCIATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | SRI INTERNATIONAL (US) | 2000-10-11 | — | — | EP | disclosed |
| US-6083941-A | TREATMENT OF NEUROPATHIC PAIN, DRUG WITHDRAWAL/DEPENDENCY, EPILEPSY, GLAUCOMA, CHRONIC NEURODEGENERATIVE DISEASES, AMYOTROPHIC LATERAL SCLEROSIS, ANXIETY DISORDERS, BRAIN CELL DEATH, ISCHAEMIA, STROKE, TRAUMA | TRUSTEES OF BOSTON UNIVERSITY (US) | 2000-07-04 | — | — | US | disclosed |
| US-6046186-A | ANTITUMOR AGENTS, ANTICARCINOGENIC AGENTS | SRI INTERNATIONAL (US) | 2000-04-04 | — | — | US | disclosed |
| WO-1999033858-A9 | ESTRONE SULFAMATE INHIBITORS OF ESTRONE SULFATASE, AND ASSOCIATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | STANFORD RES INST INT (US) | 1999-10-28 | — | — | WO | disclosed |
| WO-1999033858-A2 | ESTRONE SULFAMATE INHIBITORS OF ESTRONE SULFATASE, AND ASSOCIATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | SRI INTERNATIONAL (US) | 1999-07-08 | — | — | WO | disclosed |
| EP-0840612-A1 | INHIBITION OF NMDA RECEPTOR ACTIVITY BY PREGNENOLONE SULFATE DERIVATIVES | TRUSTEES OF BOSTON UNIVERSITY (US) | 1998-05-13 | — | — | EP | disclosed |
| WO-1997003677-A1 | INHIBITION OF NMDA RECEPTOR ACTIVITY BY PREGNENOLONE SULFATE DERIVATIVES | TRUSTEES OF BOSTON UNIVERSITY (US) | 1997-02-06 | — | — | WO | disclosed |
| US-3939186-A | Process for producing ethers of steroids | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JA) | 1976-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12139508-B2 | Steroid derivative regulators, method for preparing the same, and uses thereof | GABRD, GABRR1, GABRA1 | LMNA 3740/4885CYP3A4 105/4885KMT2A 4408/4885 |
| US-11234991-B2 | Methods for the separation and detection of an oxysterol | OSBP2, NR1H3, OSBP | LMNA 554/4885CYP3A4 556/4885KMT2A 4870/4885 |
| US-11324759-B2 | Oxysterol-statin compounds for bone growth | HMGCR, SOST, OSBP2 | LMNA 3608/4885CYP3A4 350/4885KMT2A 4672/4885 |
| US-11384114-B2 | Polymorphic forms of an oxysterol and methods of making them | HSD3B1, VKORC1L1, VKORC1 | LMNA 874/4885CYP3A4 60/4885KMT2A 4813/4885 |
| US-20250051387-A1 | STEROID DERIVATIVE REGULATORS, METHOD FOR PREPARING THE SAME, AND USES THEREOF | GABRD, GABRR1, GABRA1 | LMNA 3740/4885CYP3A4 105/4885KMT2A 4408/4885 |
| US-20210238218-A1 | COMPOUNDS AND METHODS OF MAKING STEROLS USING DIOLS | DHCR7, LSS, HSD17B7 | LMNA 1545/4885CYP3A4 131/4885KMT2A 4327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.