SCHEMBL8840937

SCHEMBL8840937

Cc1ccc2c3ccc(C)cc3c3cc(C)c(C)cc3c2c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.46
CYP2A6 P11509 4/20 0.46
ALDH1A1 P00352 4/20 0.43
KDM4E B2RXH2 2/20 0.43
HPGD P15428 2/20 0.43
HSD17B10 Q99714 2/20 0.43
LMNA P02545 2/20 0.43
GAA P10253 1/20 0.43
TDP1 Q9NUW8 5/20 0.42
TP53 P04637 2/20 0.42
ALOX15 P16050 2/20 0.40
MAPT P10636 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40
ACHE P22303 2/20 0.39
KIF11 P52732 1/20 0.38
CYP3A4 P08684 1/20 0.38
THRB P10828 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
TRPA1 O75762 1/20 0.38
LDHA P00338 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3873030 0.91 CYP1A2 (0.50) CYP1A2CYP2A6ALDH1A1KDM4EHPGD
SCHEMBL8840917 0.91 CYP1A2 (0.50) CYP1A2CYP2A6ALDH1A1KDM4EHPGD
SCHEMBL17180585 0.82 KIF11 (0.54) CYP1A2CYP2A6LMNAGAATDP1
SCHEMBL8840916 0.82 KIF11 (0.54) CYP1A2CYP2A6LMNAGAATDP1
SCHEMBL8840903 0.79 ESR1 (0.42) CYP1A2CYP2A6ALDH1A1KDM4EHPGD
SCHEMBL1134728 0.77 TSHR (0.41) CYP1A2CYP2A6ALDH1A1KDM4EHPGD
SCHEMBL4888023 0.77 CYP1A2 (0.52) CYP1A2CYP2A6ALDH1A1KDM4EHPGD
SCHEMBL29845621 0.77 CYP1A2 (0.52) CYP1A2CYP2A6ALDH1A1KDM4EHPGD
SCHEMBL13924647 0.76 MEN1 (0.42) CYP1A2CYP2A6ALDH1A1KDM4EHSD17B10
SCHEMBL12070599 0.76 MEN1 (0.47) CYP1A2CYP2A6ALDH1A1KDM4EHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5637669-A THERMOSETTING RESIN; LIQUID CRYSTALLINE POLYMERS THE DOW CHEMICAL COMPANY (US) 1997-06-10 US disclosed
EP-0670856-A1 THERMOSETTABLE COMPOSITION CONTAINING MESOGENIC MOIETIES THE DOW CHEMICAL COMPANY (US) 1995-09-13 EP disclosed
WO-1994012556-A2 THERMOSETTABLE COMPOSITION CONTAINING DISCOTIC MESOGENIC MOIETIES THE DOW CHEMICAL COMPANY (US) 1994-06-09 WO disclosed