Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.43 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 9/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29699515 | 0.82 | MEN1 (0.37) | ABCG2ABCB1ABCC1FBP1KDM4E | |
| SCHEMBL23457500 | 0.82 | MEN1 (0.37) | ABCG2ABCB1ABCC1FBP1KDM4E | |
| SCHEMBL15831504 | 0.80 | MAPT (0.43) | RAPGEF4EGFRKDM4ECDK1MAPT | |
| SCHEMBL3957483 | 0.80 | NPSR1 (0.50) | EGFRERBB2ABL1CYP1A2CYP3A4 | |
| SCHEMBL828555 | 0.78 | MEN1 (0.48) | ABCG2HTR2BAURKAKDM4ECYP1A2 | |
| SCHEMBL16881732 | 0.75 | EGFR (0.46) | ABCG2ABCB1ABCC1RAPGEF4EGFR | |
| SCHEMBL8842950 | 0.73 | EGFR (0.44) | ABCG2ABCB1ABCC1RAPGEF4EGFR | |
| SCHEMBL1687027 | 0.73 | RAPGEF4 (0.61) | ABCG2RAPGEF4EGFRIDO1HTR1A | |
| SCHEMBL29961149 | 0.73 | RAPGEF4 (0.61) | ABCG2RAPGEF4EGFRIDO1HTR1A | |
| SCHEMBL29961547 | 0.73 | RAPGEF4 (0.61) | ABCG2RAPGEF4EGFRIDO1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5679683-A | USEFUL FOR TREATING CANCER, ARTHRITIS, PSORIASIS, VASCULAR RESTENOSIS AND ANGIOGENESIS | WARNER-LAMBERT COMPANY (US) | 1997-10-21 | — | — | US | disclosed |