Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2711098 | 0.79 | MRGPRX4 (0.46) | LOXL2PIK3CA | |
| SCHEMBL10608721 | 0.79 | MEN1 (0.42) | MEN1KMT2ACYP19A1IKBKBCYP11B1 | |
| SCHEMBL8842468 | 0.79 | MEN1 (0.50) | MEN1KMT2AHRH3METGAA | |
| SCHEMBL2710917 | 0.78 | MYC (0.47) | JAK2MAPK14PIK3CA | |
| SCHEMBL6416179 | 0.77 | TSHR (0.52) | MEN1KMT2ACYP19A1IKBKBHRH3 | |
| SCHEMBL8886940 | 0.76 | ABCG2 (0.53) | MEN1KMT2AIKBKBJAK2GAA | |
| SCHEMBL28172766 | 0.75 | AURKA (0.52) | MEN1KMT2ACYP11B1CYP11B2PIK3CA | |
| SCHEMBL8842611 | 0.74 | NISCH (0.54) | — | |
| SCHEMBL4378433 | 0.73 | MEN1 (0.48) | MEN1KMT2ACYP19A1IKBKBJAK2 | |
| SCHEMBL398890 | 0.72 | CYP11B1 (0.58) | CYP19A1CYP11B1HRH3LOXL2CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686456-A | DIARYLPYRIMIDINES | THE UNIVERSITY OF NORTH CAROLINA (US) | 1997-11-11 | — | — | US | disclosed |
| US-5627184-A | BACTERICIDES OF PYRIMIDINE DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1997-05-06 | — | — | US | disclosed |
| US-5622955-A | ADMINISTERING 2,4-BIS-/4-GUANYLPHENYL/-PYRIMIDINE OR DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1997-04-22 | — | — | US | disclosed |
| US-5606058-A | HAVING REDUCED SIDE EFFECTS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1997-02-25 | — | — | US | disclosed |
| US-5521189-A | PYRIMIDINE COMPOUNDS AS ANTIPROTOZOA AGENTS | THE UNIVERSITY OF NC AT CH (US) | 1996-05-28 | — | — | US | disclosed |