Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 9/20 | 0.58 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | MLNR | O43193 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.43 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.42 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8378028 | 0.85 | CYP2A6 (0.58) | CYP11B1CYP11B2KDM1AKDM4EALDH1A1 | |
| SCHEMBL2304494 | 0.82 | SMN1; SMN2 (0.58) | CYP11B1KDM1AKDM4EALDH1A1HPGD | |
| SCHEMBL9021143 | 0.81 | KDM1A (0.58) | CYP11B1CYP11B2KDM1AKDM4EALDH1A1 | |
| SCHEMBL13986853 | 0.81 | KDM4E (0.59) | CYP11B1CYP11B2KDM1AKDM4EALDH1A1 | |
| SCHEMBL9637460 | 0.81 | CYP11B1 (0.53) | CYP11B1KDM1AKDM4EALDH1A1HPGD | |
| SCHEMBL8377287 | 0.80 | RAB9A (0.67) | CYP11B1KDM1AKDM4EALDH1A1HPGD | |
| SCHEMBL10555916 | 0.80 | SMN1; SMN2 (0.56) | CYP11B1KDM1AKDM4EALDH1A1HPGD | |
| SCHEMBL10556013 | 0.80 | CYP2A6 (0.56) | CYP11B1KDM1AKDM4EALDH1A1HPGD | |
| SCHEMBL9022425 | 0.80 | KDM4E (0.58) | CYP11B1CYP11B2KDM1AKDM4EALDH1A1 | |
| SCHEMBL9021665 | 0.79 | KDM4E (0.61) | CYP11B1CYP11B2KDM1AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188121-B2 | Substituted pyridines as antiparasitic AZA teraryl compounds | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2012-05-29 | — | — | US | disclosed |
| US-8101636-B2 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2012-01-24 | — | — | US | disclosed |
| US-8101636-B2 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2012-01-24 | — | — | US | disclosed |
| US-20110257199-A1 | NOVEL TERARYL COMPOUNDS AS ANTIPARASITIC AGENTS | TIDWELL RICHARD R | 2011-10-20 | — | — | US | disclosed |
| US-7964619-B2 | Teraryl components as antiparasitic agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2011-06-21 | — | — | US | disclosed |
| EP-1949896-A2 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | The University of North Carolina At Chapel Hill (US) | 2008-07-30 | — | — | EP | disclosed |
| US-20070232621-A1 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2007-10-04 | — | — | US | disclosed |
| US-20060293328-A1 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | TIDWELL RICHARD R | 2006-12-28 | — | — | US | disclosed |
| EP-1736466-A1 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | The University of North Carolina at Chapel Hill (US) | 2006-12-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232621-A1 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | TPMT, TYMS, DDT | CYP11B1 3003/4885CYP11B2 2922/4885KDM1A 811/4885 |
| US-20110257199-A1 | NOVEL TERARYL COMPOUNDS AS ANTIPARASITIC AGENTS | DDT, ZC3HAV1, MAVS | CYP11B1 1588/4885CYP11B2 1478/4885KDM1A 1454/4885 |
| US-20060293328-A1 | Linear dicationic terphenyls and their aza analogues as antiparasitic agents | TPMT, TYMS, DDT | CYP11B1 3003/4885CYP11B2 2922/4885KDM1A 811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.