Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | ALPL | P05186 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17966223 | 0.80 | ALDH1A1 (0.59) | ALPLRAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6852929 | 0.75 | CA12 (0.50) | CA12ALPLCA9RAB9AALDH1A1 | |
| SCHEMBL1753182 | 0.74 | HPGDS (0.60) | RAB9AALDH1A1SMN1; SMN2MAPTTP53 | |
| SCHEMBL11070857 | 0.72 | RXFP1 (0.46) | CA12ALPLCA9RAB9AALDH1A1 | |
| SCHEMBL8842683 | 0.72 | ALDH1A1 (0.56) | CA12ALPLCA9RAB9AALDH1A1 | |
| SCHEMBL17966240 | 0.71 | SMN1; SMN2 (0.60) | CA12CA9RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL19625068 | 0.71 | KDM4E (0.55) | RAB9AALDH1A1SMN1; SMN2MAPTTP53 | |
| SCHEMBL4683639 | 0.69 | GRK6 (0.45) | ALDH1A1MAPTNOTUMDHODH | |
| SCHEMBL31014274 | 0.69 | ATM (0.67) | RAB9AALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL4678365 | 0.69 | MAP2K4 (0.48) | RAB9AHSP90AA1HSP90AB1MAPTNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5674887-A | Prevention of bone resorption | ELI LILLY AND COMPANY (US) | 1997-10-07 | — | — | US | disclosed |
| EP-0578477-B1 | Treatment of inflammatory bowel disease | LILLY CO ELI (US) | 1996-06-19 | — | — | EP | disclosed |
| US-5436258-A | Prevention of bone resorption | ELI LILLY AND COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0587378-A1 | Prevention of bone resorption | ELI LILLY AND COMPANY (US) | 1994-03-16 | — | — | EP | disclosed |
| US-5294630-A | Treatment of inflammatory bowel disease | ELI LILLY AND COMPANY (US) | 1994-03-15 | — | — | US | disclosed |
| EP-0578477-A1 | Treatment of inflammatory bowel disease | ELI LILLY AND COMPANY (US) | 1994-01-12 | — | — | EP | disclosed |