⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7324700 | 0.93 | — | — | |
| SCHEMBL7331753 | 0.93 | MDM2 (0.31) | — | |
| SCHEMBL7324426 | 0.92 | — | — | |
| Trifluoroacetic Acid SCHEMBL8842983 | 0.92 | RXRA (0.30) | — | |
| SCHEMBL7324082 | 0.91 | MDM2 (0.33) | — | |
| SCHEMBL7358111 | 0.87 | MDM2 (0.31) | — | |
| Trifluoroacetic Acid SCHEMBL7324690 | 0.86 | MDM2 (0.30) | — | |
| SCHEMBL7328925 | 0.85 | MDM2 (0.32) | — | |
| SCHEMBL7321439 | 0.84 | — | — | |
| SCHEMBL7329548 | 0.84 | MDM2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663166-A | ANTICOAGULANTS OF 1,4-BENZODIAZEPINE-2,5-DIONE AND 2-BENZOAZEPINE-1,4-DIONE DERIVATIVES; PREVENTS FIBRINOGEN BINDING NECESSARY FOR PLATELET AGGREGATION; SIDE EFFECT REDUCTION, E.G. EXCESSIVE BLEEDING | GENENTECH, INC. (US) | 1997-09-02 | — | — | US | disclosed |
| US-5565449-A | PLATELET AGGREGATION INHIBITORS | GENENTECH, INC. (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0610334-B1 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII B III A RECEPTOR | GENENTECH INC (US) | 1996-01-24 | — | — | EP | disclosed |