SCHEMBL8842998

SCHEMBL8842998

COc1ccccc1C(=O)Nc1nc2c(s1)CN(C)CC2

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.66
RAB9A P51151 2/20 0.66
CYP1A2 P05177 1/20 0.66
CYP2D6 P10635 1/20 0.66
HPGD P15428 1/20 0.66
CYP2C19 P33261 1/20 0.66
F10 P00742 2/20 0.59
ALOX15 P16050 1/20 0.59
ROCK2 O75116 10/20 0.58
KDM4E B2RXH2 2/20 0.57
MAPT P10636 2/20 0.56
MEN1 O00255 1/20 0.56
ALDH1A1 P00352 1/20 0.56
HTT P42858 1/20 0.56
KMT2A Q03164 1/20 0.56
SMN1; SMN2 Q16637 1/20 0.56
PKM P14618 1/20 0.55
PAX8 Q06710 1/20 0.55
L3MBTL1 Q9Y468 1/20 0.55
GAA P10253 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9574547 0.92 NPC1 (0.55) NPC1RAB9ACYP1A2CYP2D6HPGD
SCHEMBL8843033 0.86 NPC1 (0.59) NPC1RAB9ACYP1A2CYP2D6HPGD
SCHEMBL3096109 0.82 GAA (0.73) NPC1RAB9ACYP1A2CYP2D6HPGD
SCHEMBL8843680 0.79 F10 (0.64) F10
SCHEMBL9574549 0.78 MEN1 (0.51) NPC1RAB9ACYP1A2CYP2D6HPGD
Fumaric Acid SCHEMBL8843096 0.78 ALDH1A1 (0.57) NPC1RAB9ACYP1A2CYP2D6HPGD
Fumaric Acid SCHEMBL8843089 0.78 ALDH1A1 (0.57) NPC1RAB9ACYP1A2CYP2D6HPGD
SCHEMBL112005 0.77 GRAMD1A (0.53) NPC1RAB9ACYP1A2CYP2D6HPGD
SCHEMBL4247062 0.76 NPC1 (0.55) NPC1RAB9ACYP1A2CYP2D6HPGD
SCHEMBL12307367 0.76 KDM4E (0.55) NPC1RAB9ACYP1A2CYP2D6HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5424431-A Shows selective agonistic activity for 5-HT3 receptor, useful drug for digestive disorder YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1995-06-13 US claimed
US-5656637-A SEROTONIN RECEIVER ANTAGONIST; PSYCHOLOGICAL DISORDERS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1997-08-12 US disclosed
US-5424431-A Shows selective agonistic activity for 5-HT3 receptor, useful drug for digestive disorder YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1995-06-13 US disclosed